ReviewCurrent opinion in chemical biology2010
Chemically modified antibodies as diagnostic imaging agents.
Review in Current opinion in chemical biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- Pretargeting: A Path Forward for Radioimmunotherapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022Review
- Simple, Rapid Chemical Labeling and Screening of Antibodies with Luminescent Peptides.ACS chemical biology · 2022Article
- SNAP-Tag Technology: A Promising Tool for Ex Vivo Immunophenotyping.Molecular diagnosis & therapy · 2017Article
- Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering.Chemical science · 2017Article
- Antibody Labeling with Fluorescent Dyes Using Magnetic Protein A and Protein G Beads.Journal of visualized experiments : JoVE · 2016Article
- Next-generation disulfide stapling: reduction and functional re-bridging all in one.Chemical science · 2016Article
- The radiolabeling of proteins by the [18F]AlF method.Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2012Article
- Rapid chemoselective bioconjugation through oxidative coupling of anilines and aminophenols.Journal of the American Chemical Society · 2011Article
- New covalent capture probes for imaging and therapy, based on a combination of binding affinity and disulfide bond formation.Bioconjugate chemistry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Notable new applications of antibodies for imaging involve genetically extracting the essential molecular recognition properties of an antibody, and in some cases enhancing them by mutation, before protein expression. The classic paradigm of intravenous administration of a labeled antibody to image not only its target but also its metabolism can be improved on. Protocols involving molecular targeting with an engineered unlabeled protein derived from an antibody, followed by capture of a small probe molecule that provides a signal, are being developed to a high level of utility. This is accompanied by new strategies for probe capture such as irreversible binding, incorporation of engineered enzyme active sites, and antibody-ligand systems that generate a signal only upon binding or uptake.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.