ReviewSeminars in cancer biology2010
Passenger mutations as a marker of clonal cell lineages in emerging neoplasia.
Review in Seminars in cancer biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- A Revised Stem Cell Theory for the Pathogenesis of Endometriosis.Journal of personalized medicine · 2022Review
- Duplex-Repair enables highly accurate sequencing, despite DNA damage.Nucleic acids research · 2022Article
- Teaching cancer imaging in the era of precision medicine: Looking at the big picture.European journal of radiology open · 2022Review
- Next-Generation Genotoxicology: Using Modern Sequencing Technologies to Assess Somatic Mutagenesis and Cancer Risk.Environmental and molecular mutagenesis · 2020Review
- High-throughput dense reconstruction of cell lineages.Open biology · 2019Article
- Precancer in ulcerative colitis: the role of the field effect and its clinical implications.Carcinogenesis · 2018Review
- The evolution of tumour phylogenetics: principles and practice.Nature reviews. Genetics · 2017Review
- Canine spontaneous head and neck squamous cell carcinomas represent their human counterparts at the molecular level.PLoS genetics · 2015Article
- Using tumour phylogenetics to identify the roots of metastasis in humans.Nature reviews. Clinical oncology · 2015Review
- Hypermutable DNA chronicles the evolution of human colon cancer.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.Inflammatory bowel diseases · 2013Article
- Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality.British journal of cancer · 2012Article
- Article
- Next-generation sequencing methodologies to detect low-frequency mutations: "Catch me if you can".Mutation research. Reviews in mutation researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cancer arises as the result of a natural selection process among cells of the body, favoring lineages bearing somatic mutations that bestow them with a proliferative advantage. Of the thousands of mutations within a tumor, only a small fraction functionally drive its growth; the vast majority are mere passengers of minimal biological consequence. Yet the presence of any mutation, independent of its role in facilitating proliferation, tags a cell's clonal descendants in a manner that allows them to be distinguished from unrelated cells. Such markers of cell lineage can be used to identify the abnormal proliferative signature of neoplastic clonal evolution, even at a stage which predates morphologically recognizable dysplasia. This article focuses on molecular techniques for assessing cellular clonality in humans with an emphasis on how they may be used for early detection of tumorigenic processes. We discuss historical as well as contemporary approaches and consider ways in which powerful new genomic technologies might be harnessed to develop a future generation of early cancer diagnostics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.