ArticleReproductive toxicology (Elmsford, N.Y.)2011
Akt1 protects against germ cell apoptosis in the postnatal mouse testis following lactational exposure to 6-N-propylthiouracil.
Article in Reproductive toxicology (Elmsford, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 23 citations in OpenAlex.
- Identification of AKT1 and related ncRNAs hsa-miR-1286 and linc00242 as a putative molecular pathway in men with asthenozoospermia.Molecular biology reports · 2026Article
- Exploration of the active components and mechanisms of Epimedium for the treatment of Undescended Testis.Frontiers in endocrinology · 2025Article
- Combined analysis of mRNA-miRNA from testis tissue in Tibetan sheep with different FecB genotypes.Open life sciences · 2023Article
- The PI3K/AKT signaling pathway: How does it regulate development of Sertoli cells and spermatogenic cells?Histology and histopathology · 2022Review
- An integrative approach to uncover the components, mechanisms, and functions of traditional Chinese medicine prescriptions on male infertility.Frontiers in pharmacology · 2022Article
- Network pharmacology integrated molecular docking reveals the bioactive components and potential targets of Morinda officinalis-Lycium barbarum coupled-herbs against oligoasthenozoospermia.Scientific reports · 2021Article
- An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the New Candidate Active Component and Mechanism ofDrug design, development and therapy · 2021Article
- Thyroid Hormone Deiodination and Action in the Gonads.Current opinion in endocrine and metabolic research · 2018Article
- The protective effect of FGF21 on diabetes-induced male germ cell apoptosis is associated with up-regulated testicular AKT and AMPK/Sirt1/PGC-1α signaling.Endocrinology · 2015Article
- Article
- The blood-testis barrier and its implications for male contraception.Pharmacological reviews · 2012Review
- Decreased spermatogenesis, fertility, and altered Slc2A expression in Akt1-/- and Akt2-/- testes and sperm.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Exposure to 6-propyl-2-thio-uracil (PTU), a neonatal goitrogen, leads to increased testis size and sperm production in rodents. Akt1, a gene involved in cell survival and proliferation is also phosphorylated by thyroxine (T(4)). Therefore, we examined the requirement for Akt1 in germ cell survival following PTU-induced hypothyroidism. Experiments were performed using Akt1+/+, Akt1+/-, and Akt1-/- mice. PTU was administered (0.01% w/v) via the drinking water of dams from birth to PND21. At PND15, T(4) serum levels were similar in all control groups, and significantly lower in all exposed groups with a dramatic decrease in Akt1-/- mice. PTU-exposed Akt1-/- testes displayed smaller tubules, increased apoptosis, delayed lumen formation, and increased inhibin B and AMH mRNA. Relative adult testis weights were similar in all exposure groups; however, no increase in daily sperm production was observed in PTU-exposed Akt1-/- mice. In conclusion, Akt1 contributes to the effects of thyroid hormone on postnatal testis development.
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Registered trials
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