ReviewPharmacology & therapeutics2011
The impact of redox and thiol status on the bone marrow: Pharmacological intervention strategies.
Review in Pharmacology & therapeutics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Imidazole-2-thione derivatives as new selective anticancer agents with anti-metastatic properties: synthesis and pharmacological evaluation.Journal of enzyme inhibition and medicinal chemistry · 2026Article
- Selenylated Imidazo[1,2Molecules (Basel, Switzerland) · 2023Article
- Thioredoxin 1 is upregulated in the bone and bone marrow following experimental myocardial infarction: evidence for a remote organ response.Histochemistry and cell biology · 2021Article
- Differential regulation of CaScience signaling · 2019Article
- MGST1, a GSH transferase/peroxidase essential for development and hematopoietic stem cell differentiation.Redox biology · 2018Article
- Article
- Olaparib, Monotherapy or with Ionizing Radiation, Exacerbates DNA Damage in Normal Tissues: Insights from a New p21 Reporter Mouse.Molecular cancer research : MCR · 2016Article
- S-glutathionylation of buccal cell proteins as biomarkers of exposure to hydrogen peroxide.BBA clinical · 2014Article
- Hydrogen peroxide (H2O2) induces leukemic but not normal hematopoietic cell death in a dose-dependent manner.Cancer cell international · 2013Article
- Causes and consequences of cysteine S-glutathionylation.The Journal of biological chemistry · 2013Review
- Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia.Journal of leukocyte biology · 2013Review
- ROS-mediated platelet generation: a microenvironment-dependent manner for megakaryocyte proliferation, differentiation, and maturation.Cell death & disease · 2013Review
- In vivo response to dynamic hyaluronic acid hydrogels.Acta biomaterialia · 2013Article
- Oxidases and reactive oxygen species during hematopoiesis: a focus on megakaryocytes.Journal of cellular physiology · 2012Review
- Processing of CXCL12 by different osteoblast-secreted cathepsins.Stem cells and development · 2012Article
- S-glutathionylated serine proteinase inhibitors as plasma biomarkers in assessing response to redox-modulating drugs.Cancer research · 2012Article
- NADPH oxidase 2 regulates bone marrow microenvironment following hindlimb ischemia: role in reparative mobilization of progenitor cells.Stem cells (Dayton, Ohio) · 2012Article
- Hydrogen peroxide fuels aging, inflammation, cancer metabolism and metastasis: the seed and soil also needs "fertilizer".Cell cycle (Georgetown, Tex.) · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Imbalances in cancer cell redox homeostasis provide a platform for new opportunities in the development of anticancer drugs. The control of severe dose-limiting toxicities associated with redox regulation, including myelosuppression and immunosuppression, remains a challenge. Recent evidence implicates a critical role for redox regulation and thiol balance in pathways that control myeloproliferation, hematopoietic progenitor cell mobilization, and immune response. Hematopoietic stem cell (HSC) self-renewal and differentiation are dependent upon levels of intracellular reactive oxygen species (ROS) and niche microenvironments. Redox status and the equilibrium of free thiol:disulfide couples are important in modulating immune response and lymphocyte activation, proliferation and differentiation. This subject matter is the focus of the present review. The potential of redox modulating chemotherapeutics as myeloproliferative and immunomodulatory agents is also covered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.