ArticleJournal of molecular and cellular cardiology2011
Expression and roles of Cav1.3 (α1D) L-type Ca²+ channel in atrioventricular node automaticity.
Article in Journal of molecular and cellular cardiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Impact of CaInternational journal of molecular sciences · 2026Review
- An optimized Langendorff-free isolating method and electrophysiology studies for adult mouse atrioventricular node cells.BMC cardiovascular disorders · 2025Article
- Transcriptional regulation of the postnatal cardiac conduction system heterogeneity.Nature communications · 2024Article
- Advanced Atrioventricular Block in Athletes: Prevalence and Role of Anti-Ro/Sjögren Syndrome-Related Antigen A Antibodies.Journal of the American Heart Association · 2024Article
- Characterization of pathological remodeling in the chronic atrioventricular block cynomolgus monkey heart.Frontiers in pharmacology · 2023Article
- The effect of alterations of schizophrenia-associated genes on gamma band oscillations.Schizophrenia (Heidelberg, Germany) · 2022Article
- Pharmacologic Approach to Sinoatrial Node Dysfunction.Annual review of pharmacology and toxicology · 2021Review
- Concomitant genetic ablation of L-type CaScientific reports · 2020Article
- Alterations in Schizophrenia-Associated Genes Can Lead to Increased Power in Delta Oscillations.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Computational Modeling of Genetic Contributions to Excitability and Neural Coding in Layer V Pyramidal Cells: Applications to Schizophrenia Pathology.Frontiers in computational neuroscience · 2019Article
- Mutations in voltage-gated L-type calcium channel: implications in cardiac arrhythmia.Channels (Austin, Tex.) · 2018Review
- At the Atrioventricular Crossroads: Dual Pathway Electrophysiology in the Atrioventricular Node and its Underlying Heterogeneities.Arrhythmia & electrophysiology review · 2017Article
- Pleiotropic effects of schizophrenia-associated genetic variants in neuron firing and cardiac pacemaking revealed by computational modeling.Translational psychiatry · 2017Article
- Transmural gradients in ion channel and auxiliary subunit expression.Progress in biophysics and molecular biology · 2016Review
- Interactions of Short-Term and Chronic Treadmill Training With Aging of the Left Ventricle of the Heart.The journals of gerontology. Series A, Biological sciences and medical sciences · 2016Article
- Functional Effects of Schizophrenia-Linked Genetic Variants on Intrinsic Single-Neuron Excitability: A Modeling Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
- Mechanisms underlying the cardiac pacemaker: the role of SK4 calcium-activated potassium channels.Acta pharmacologica Sinica · 2016Review
- Electrophysiological properties of myocytes isolated from the mouse atrioventricular node: L-type ICa, IKr, If, and Na-Ca exchange.Physiological reports · 2015Article
- Characterization of L-type calcium channel activity in atrioventricular nodal myocytes from rats with streptozotocin-induced Diabetes mellitus.Physiological reports · 2015Article
- RNA sequencing of mouse sinoatrial node reveals an upstream regulatory role for Islet-1 in cardiac pacemaker cells.Circulation research · 2015Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 3 countries.
Funding
Abstract
Atrioventricular node (AV node) is the hub where electrical input from the atria is propagated and conveyed to the ventricles. Despite its strategic position and role in governing impulse conduction between atria and ventricles, there is paucity of data regarding the contribution of specific ion channels to the function of the AV node. Here, we examined the roles of Ca(v)1.3 L-type Ca(2+) channel in AV node by taking advantage of a mouse model with null mutation of Ca(v)1.3 (Ca(v)1.3(-/-)). Ca(v)1.3 null mutant mice show evidence of AV node dysfunction with AV block, suggesting the tissue-specific function of the Ca(v)1.3 channel. In keeping with this assertion, we demonstrate that Ca(v)1.3 isoform is highly expressed in the isolated AV node cells. Furthermore, AV node isolated from Ca(v)1.3 null mutant mice show a significant decrease in the firing frequency of spontaneous action potentials suggesting that Ca(v)1.3 L-type Ca(2+) channel plays significant roles in the automaticity of the AV node. Because of the distinct voltage-dependence of Ca(v)1.2 and Ca(v)1.3 Ca(2+) channels, Ca(v)1.2 alone does not suffice to maintain normal AV node function. Ca(v)1.3 currents activate at more hyperpolarizing voltage compared to Ca(v)1.2 currents. Consequently, Ca(v)1.2 Ca(2+) channel cannot functionally substitute for Ca(v)1.3 isoform in the AV node of Ca(v)1.3 null mutant mice. Thus, our study demonstrates that the distinct biophysical properties of Ca(v)1.3 Ca(2+) channel play critical roles in the firing frequency of AV node tissues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.