ArticleBiomaterials2011
Evaluation of gel spun silk-based biomaterials in a murine model of bladder augmentation.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 107 citations in OpenAlex.
- Evaluation of Bi-layer Silk Fibroin Grafts for Onlay Urethroplasty in a Female Porcine Model of Long Urethral Strictures.Tissue engineering and regenerative medicine · 2025Article
- Enhanced Bladder Regeneration with Adipose-Derived Stem Cell-Seeded Silk Fibroin Scaffolds: A Comparative Analysis.Biomimetics (Basel, Switzerland) · 2025Article
- Engineering the Future of Bladder Repair: Can Biocompatible 3D-Printed Scaffolds Serve as a Novel Alternative to Intestinal Segments for the Treatment of Bladder Exstrophy?Advances in urology · 2025Article
- Tissue Engineering and Regenerative Medicine in Pediatric Urology: Urethral and Urinary Bladder Reconstruction.International journal of molecular sciences · 2022Review
- Porcine Small Intestinal Submucosa (SIS) as a Suitable Scaffold for the Creation of a Tissue-Engineered Urinary Conduit: Decellularization, Biomechanical and Biocompatibility Characterization Using New Approaches.International journal of molecular sciences · 2022Article
- The Significance of Biomechanics and Scaffold Structure for Bladder Tissue Engineering.International journal of molecular sciences · 2021Review
- Non-Muscular Invasive Bladder Cancer: Re-envisioning Therapeutic Journey from Traditional to Regenerative Interventions.Aging and disease · 2021Review
- Evaluation of Bilayer Silk Fibroin Grafts for Tubular Esophagoplasty in a Porcine Defect Model.Tissue engineering. Part A · 2021Article
- Current Applications and Future Directions of Bioengineering Approaches for Bladder Augmentation and Reconstruction.Frontiers in surgery · 2021Review
- [Advance in functional bladder engineering].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Review
- Evaluation of Poly (Carbonate-Urethane) Urea (PCUU) Scaffolds for Urinary Bladder Tissue Engineering.Annals of biomedical engineering · 2019Article
- Tissue Engineering in Pediatric Bladder Reconstruction-The Road to Success.Frontiers in pediatrics · 2019Review
- Repair of injured urethras with silk fibroin scaffolds in a rabbit model of onlay urethroplasty.The Journal of surgical research · 2018Article
- Bioengineering Approaches for Bladder Regeneration.International journal of molecular sciences · 2018Review
- Tissue engineering in pediatric urology - a critical appraisal.Innovative surgical sciences · 2018Review
- Bladder biomechanics and the use of scaffolds for regenerative medicine in the urinary bladder.Nature reviews. Urology · 2018Review
- Bi-layer silk fibroin grafts support functional tissue regeneration in a porcine model of onlay esophagoplasty.Journal of tissue engineering and regenerative medicine · 2018Article
- Native-mimicking in vitro microenvironment: an elusive and seductive future for tumor modeling and tissue engineering.Journal of biological engineering · 2018Review
- Mode of Surgical Injury Influences the Source of Urothelial Progenitors during Bladder Defect Repair.Stem cell reports · 2017Article
- The morphological regeneration and functional restoration of bladder defects by a novel scaffold and adipose-derived stem cells in a rat augmentation model.Stem cell research & therapy · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Currently, gastrointestinal segments are considered the gold standard for bladder reconstructive procedures. However, significant complications including chronic urinary tract infection, metabolic abnormalities, urinary stone formation, bowel dysfunction, and secondary malignancies are associated with this approach. Biomaterials derived from silk fibroin may represent a superior alternative due their robust mechanical properties, biodegradable features, and processing plasticity. In the present study, we evaluated the efficacy of a gel spun silk-based matrix for bladder augmentation in a murine model. Over the course of 70 d implantation period, H&E and Masson's trichrome (MTS) analysis revealed that silk matrices were capable of supporting both urothelial and smooth muscle regeneration at the defect site. Prominent uroplakin and contractile protein expression (α-actin, calponin, and SM22α) was evident by immunohistochemical analysis demonstrating maturation of the reconstituted bladder wall compartments. Gel spun silk matrices also elicited a minimal acute inflammatory reaction following 70 d of bladder integration, in contrast to parallel assessments of small intestinal submucosa (SIS) and poly-glycolic acid (PGA) matrices which routinely promoted evidence of fibrosis and chronic inflammatory responses. Voided stain on paper analysis revealed that silk augmented animals displayed similar voiding patterns in comparison to non surgical controls by 42 d of implantation. In addition, cystometric evaluations of augmented bladders at 70 d post-op demonstrated that silk scaffolds supported significant increases in bladder capacity and voided volume while maintaining similar degrees of compliance relative to the control group. These results provide evidence for the utility of gel spun silk-based matrices for functional bladder tissue engineering applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.