ReviewThe Journal of allergy and clinical immunology2010
T(H)2 heterogeneity: Does function follow form?
Review in The Journal of allergy and clinical immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Peanut oral immunotherapy differentially suppresses clonally distinct subsets of T helper cells.The Journal of clinical investigation · 2022Trial
- A phenotypically and functionally distinct human TScience translational medicine · 2017Trial
- Elucidating the immunomodulatory roles and mechanisms of CUL4B in the immune system: a comprehensive review.Frontiers in immunology · 2025Review
- TSLP shapes the pathogenic responses of memory CD4Science signaling · 2023Article
- Allergo Journal : interdisziplinare Zeitschrift fur Allergologie und Umweltmedizin : Organ der Deutschen Gesellschaft fur Allergie- und Immunitatsforschung · 2022Review
- Cytotoxic T-Lymphocyte-Associated Antigen 4 (CTLA-4)- and Programmed Death 1 (PD-1)-Mediated Regulation of Monofunctional and Dual Functional CD4Infection and immunity · 2019Article
- Study of the immunogenicity ofIranian journal of basic medical sciences · 2019Article
- [Immunology of chronic rhinosinusitis with nasal polyps as a basis for treatment with biologicals].HNO · 2019Review
- TSLP signaling in CD4Science signaling · 2018Article
- Subtyping of polyposis nasi: phenotypes, endotypes and comorbidities.Allergo journal international · 2018Review
- Parasite Antigen-Specific Regulation of Th1, Th2, and Th17 Responses in Strongyloides stercoralis Infection.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Re-defining the unique roles for eosinophils in allergic respiratory inflammation.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2014Review
- Single-cell RNA sequencing reveals T helper cells synthesizing steroids de novo to contribute to immune homeostasis.Cell reports · 2014Article
- Article
- Parasite-antigen driven expansion of IL-5(-) and IL-5(+) Th2 human subpopulations in lymphatic filariasis and their differential dependence on IL-10 and TGFβ.PLoS neglected tropical diseases · 2014Article
- Mechanisms underlying helper T-cell plasticity: implications for immune-mediated disease.The Journal of allergy and clinical immunology · 2013Review
- Mucosal immunology of tolerance and allergy in the gastrointestinal tract.Immunologic research · 2012Review
- Differential expression of CD300a/c on human TH1 and TH17 cells.BMC immunology · 2011Article
- Hierarchical IL-5 expression defines a subpopulation of highly differentiated human Th2 cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Measuring enzyme activity in single cells.Trends in biotechnology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
T(H)2 immune responses are required for the 2 fundamental pathological processes characteristic of allergic disease: IgE-mediated hypersensitivity and eosinophilic inflammation. The 3 established T(H)2 cytokines, IL-4, IL-5, and IL-13, each play a nonredundant role in allergic disease pathology. The recent explosion of T(H) subpopulations combined with the wide availability of polychromatic cytokine staining has facilitated the discovery of T(H)2 lineage heterogeneity. In this article we review T(H)2 heterogeneity and ask the following question: At what point do these subpopulations graduate from in vitro curiosities to immunologically robust therapeutic targets? We propose criteria to establish a T-cell subset as a biologically relevant entity and address the evidence to support these T(H)2 subpopulations having a unique function or specific contribution to allergic pathology or host defense.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.