Evidence map›Paper›PMID 20951159›Full record

ArticlePharmacology, biochemistry, and behavior2011

Circulating leptin levels are associated with increased craving to smoke in abstinent smokers.

Mustafa al'Absi, Stephanie Hooker, Koji Fujiwara, Falk Kiefer, Christoph von der Goltz, Tiffany Cragin, Lorentz E Wittmers

Abstract read
In one paragraph

Article in Pharmacology, biochemistry, and behavior, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Article
  9. Review
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  12. Review
  13. Reciprocal Inhibitory Interactions Between the Reward-Related Effects of Leptin and Cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2016
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  14. Review
  15. Article
  16. Article
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  18. Article
  19. Leptin influence in craving and relapse of alcoholics and smokers.Journal of clinical medicine research · 2013
    Article
  20. How Prevalent is "Food Addiction"?Frontiers in psychiatry · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mustafa al'AbsiDuluth Medical Research Institute and Department of Behavioral Sciences, University of Minnesota Medical School, Duluth, MN 55812, USA. malabsi@umn.edu
Stephanie Hooker
Koji Fujiwara
Falk Kiefer
Christoph von der Goltz
Tiffany Cragin
Lorentz E Wittmers

Funding

Stress, Appetite, and Smoking RelapseR01DA027232 · NIDA · UNIVERSITY OF MINNESOTA · PI AL'ABSI, MUSTAFA, LEE, DUSTIN CLARK · 2010 to 2025
$4.6M
Stress Response and Opioid Dysfunction in Nicotine DependenceR01DA016351 · NIDA · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA · 2003 to 2023
$4.5M
PSYCHOBIOLOGICAL MECHANISMS OF SMOKING RELAPSER21CA088272 · NCI · UNIVERSITY OF MINNESOTA DULUTH · PI AL'ABSI, MUSTAFA N · 2000 to 2001
$368k
NCI NIH HHS CA88272NCI NIH HHS R21 CA088272NIDA NIH HHS DA016351NIDA NIH HHS R01 DA016351NIDA NIH HHS R01 DA027232
6 · The paper itself

Abstract

The adipocyte hormone leptin regulates satiety and energy expenditure. Recent evidence suggests that leptin is associated with increased craving for alcohol and with shorter length of abstinence during alcohol treatment. This study examined leptin's associations with craving for cigarettes and smoking relapse among smokers interested in cessation. Participants (32 smokers; 14 women) attended a laboratory session 24h following their designated quit day where circulating leptin levels and craving for smoking were assessed. Other measures of withdrawal symptoms, affect, physical symptoms, as well as neuroendocrine and cardiovascular measures were collected before and after performing two stress tasks (public speaking and cognitive tasks). High circulating leptin levels were associated with increased craving, withdrawal symptoms, negative affect, physical symptoms, and reduced positive affect. Circulating leptin levels were not related to cardiovascular and neuroendocrine measures, responses to acute stressors, or to smoking relapse. These results indicate that circulating leptin is a promising biological marker of craving for smoking and warrant further investigation of the links between appetite regulation and nicotine dependence.

Indexed as

MotivationAdultFemaleHumansLeptinMaleMiddle AgedSmokingLeptin

Identifiers

PMID20951159
PMCPMC5763505

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.