Evidence map›Paper›PMID 20951145›Full record

ReviewLife sciences2011

A prospective on drug abuse-associated epigenetics and HIV-1 replication.

Jui Pandhare, Chandravanu Dash

Open access · greenAbstract readReview
In one paragraph

Review in Life sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
  3. Impact of cocaine abuse on HIV pathogenesis.Frontiers in microbiology · 2015
    Review
  4. Article
  5. Epigenetics, drugs of abuse, and the retroviral promoter.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jui PandhareCenter for AIDS Health Disparities Research and Department of Biochemistry and Cancer Biology, Meharry Medical College School of Medicine, Nashville,TN, USA.
Chandravanu Dash
Meharry Medical College · US

Funding

Technologies and Resources CoreU54MD007593 · NIMHD · MEHARRY MEDICAL COLLEGE · PI ADUNYAH, SAMUEL EVANS · 2012 to 2018
$24.7M
TECHNOLOGIES AND RESOURCES FOR CORE LABORATORIESU54RR026140 · NCRR · MEHARRY MEDICAL COLLEGE · PI GOODWIN, JEFFREY SHAWN · 2009 to 2011
$12.9M
Role of nucleic acid structure in HIV-1 replicationR00DA024558 · NIDA · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2009 to 2011
$805k
Mir-125b/p53/POX axis and HIV-1 induced neurological damageR03DA037779 · NIDA · MEHARRY MEDICAL COLLEGE · PI PANDHARE, JUI · 2014 to 2015
$289k
Cocaine-Induced Epigenetic Changes in CD4+ T cells and HIV-1 ReplicationR03DA030896 · NIDA · MEHARRY MEDICAL COLLEGE · PI DASH, CHANDRAVANU · 2010 to 2011
$72k
NCRR NIH HHS U54 RR026140NIDA NIH HHS R00 DA024558NIDA NIH HHS R00DA024558NIDA NIH HHS R03 DA030896NIDA NIH HHS R03 DA037779NIMHD NIH HHS U54 MD007593
6 · The paper itself

Abstract

Drugs of abuse serve as cofactors to susceptibility to HIV infection and disease progression. Although clinical reports indicate association between HIV/AIDS and drug use, the molecular mechanism of infection susceptibility and disease progression remains unclear. Drugs such as cocaine exert their addictive effects in part by epigenetic mechanisms. Given that epigenetic modifications play an important role in HIV-1 life cycle, it is essential to unravel whether drug abuse-associated epigenetic changes may contribute to HIV/AIDS. In this article we will provide a prospective on the impact of epigenetic mechanisms on HIV-1 life cycle.

Indexed as

EpigenomicsFemaleHIV-1HIV InfectionsHumansInfectious Disease Transmission, VerticalPregnancySubstance-Related DisordersTranscription, GeneticVirus IntegrationVirus LatencyVirus Replication

Identifiers

PMID20951145
PMCPMC3046297
OpenAlexW2002520162

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.