ArticleBiochemical pharmacology2011
Targeting maladaptive glutathione responses in lung disease.
Article in Biochemical pharmacology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed.
- 5-Aminosalicylic Acid Modulates the Immune Response in Chronic Beryllium Disease Subjects.Lung · 2018Trial
- Oral administration of γ-glutamylcysteine increases intracellular glutathione levels above homeostasis in a randomised human trial pilot study.Redox biology · 2017Trial
- Flavin adenine dinucleotide increases antioxidant availability and protects neonatal C57Bl6 lungs from high oxygen induced lung injury.American journal of physiology. Cell physiology · 2026Article
- Oxidative Stress and Antioxidants in Pediatric Asthma's Evolution and Management.Antioxidants (Basel, Switzerland) · 2024Review
- Anti-Inflammatory and Anti-Oxidant Properties of N-Acetylcysteine: A Fresh Perspective.Journal of clinical medicine · 2024Review
- Gene network landscape of mouse splenocytes reveals integrin complex as the A151 ODN-responsive hub molecule in the immune transcriptome.Molecular therapy. Nucleic acids · 2023Article
- Complexity of NAC Action as an Antidiabetic Agent: Opposing Effects of Oxidative and Reductive Stress on Insulin Secretion and Insulin Signaling.International journal of molecular sciences · 2022Article
- Review
- Role of pirfenidone in TGF-β pathways and other inflammatory pathways in acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection: a theoretical perspective.Pharmacological reports : PR · 2021Review
- Methodological Fallacies in the Determination of Serum/Plasma Glutathione Limit Its Translational Potential in Chronic Obstructive Pulmonary Disease.Molecules (Basel, Switzerland) · 2021Review
- Novel Antioxidant Therapy with the Immediate Precursor to Glutathione, γ-Glutamylcysteine (GGC), Ameliorates LPS-Induced Cellular Stress in In Vitro 3D-Differentiated Airway Model from Primary Cystic Fibrosis Human Bronchial Cells.Antioxidants (Basel, Switzerland) · 2020Article
- Protein thiol oxidation in the rat lung following e-cigarette exposure.Redox biology · 2020Article
- The Beneficial Effects of Antioxidants in Health And Diseases.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2020Review
- MRP1-Collateral Sensitizers as a Novel Therapeutic Approach in Resistant Cancer Therapy: An In Vitro and In Vivo Study in Lung Resistant Tumor.International journal of molecular sciences · 2020Article
- Oxidative Toxicology of Bleomycin: Role of the Extracellular Redox Environment.Current opinion in toxicology · 2019Article
- Phosgene-induced acute lung injury (ALI): differences from chlorine-induced ALI and attempts to translate toxicology to clinical medicine.Clinical and translational medicine · 2017Review
- Glutathione Depletion Accelerates Cigarette Smoke-Induced Inflammation and Airspace Enlargement.Toxicological sciences : an official journal of the Society of Toxicology · 2015Article
- Acute and subchronic exposure to air particulate matter induces expression of angiotensin and bradykinin-related genes in the lungs and heart: Angiotensin-II type-I receptor as a molecular target of particulate matter exposure.Particle and fibre toxicology · 2015Article
- Targeting the Achilles heel of multidrug-resistant cancer by exploiting the fitness cost of resistance.Chemical reviews · 2014Review
- CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung.Free radical biology & medicine · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The lung is unique being exposed directly to the atmospheric environment containing xenobiotics, pathogens, and other agents which are continuously inhaled on a daily basis. Additionally, the lung is exposed to higher ambient oxygen levels which can promote the formation of a complex number of reactive oxygen and nitrogen species. Due to this constant barrage of potential damaging agents, the lung has developed a high degree of plasticity in dealing with ever changing conditions. In the present commentary, we will focus on glutathione (GSH) as a key antioxidant in the lung airways and discuss mechanisms by which the lung uses GSH to adapt to its rapidly changing environment. We will then examine the evidence on how defective and inadequate adaptive responses can lead to lung injury, inflammation and disease. Lastly, we will examine some of the recent attempts to alter lung GSH levels with therapies in a number of human lung diseases and discuss some of the limitations of such approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.