ArticleCurrent biology : CB2010
LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning.
Article in Current biology : CB, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- ALG-1, a microRNA argonaute, promotes vulva induction inmicroPublication biology · 2024Article
- DistinctmicroPublication biology · 2022Article
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- Ras, Ral, and Rap1 in C. elegans.Methods in molecular biology (Clifton, N.J.) · 2021Article
- The multifaceted roles of microRNAs in differentiation.Current opinion in cell biology · 2020Review
- Positive autoregulation ofDevelopment (Cambridge, England) · 2020Article
- Cell Non-autonomous Function of daf-18/PTEN in the Somatic Gonad Coordinates Somatic Gonad and Germline Development in C. elegans Dauer Larvae.Current biology : CB · 2019Article
- The Signaling Network Controlling C. elegans Vulval Cell Fate Patterning.Journal of developmental biology · 2018Review
- Article
- Recent Molecular Genetic Explorations ofGenetics · 2018Article
- Article
- A bHLH Code for Sexually Dimorphic Form and Function of the C. elegans Somatic Gonad.Current biology : CB · 2017Article
- Long-Term High-Resolution Imaging of Developing C. elegans Larvae with Microfluidics.Developmental cell · 2017Article
- Determinants in the LIN-12/Notch Intracellular Domain That Govern Its Activity and Stability DuringG3 (Bethesda, Md.) · 2016Article
- Article
- A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva.BMC bioinformatics · 2015Article
- LIN-42, the Caenorhabditis elegans PERIOD homolog, negatively regulates microRNA transcription.PLoS genetics · 2014Article
- Control of cell-fate plasticity and maintenance of multipotency by DAF-16/FoxO in quiescent Caenorhabditis elegans.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans.Frontiers in genetics · 2013Article
- Dauer larva quiescence alters the circuitry of microRNA pathways regulating cell fate progression in C. elegans.Development (Cambridge, England) · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Studies of C. elegans vulval development have illuminated mechanisms underlying cell fate specification and elucidated intercellular signaling pathways [1]. The vulval precursor cells (VPCs) are spatially patterned during the L3 stage by the EGFR-Ras-MAPK-mediated inductive signal and the LIN-12/Notch-mediated lateral signal. The pattern is both precise and robust [2] because of crosstalk between these pathways [3]. Signaling is also regulated temporally, because constitutive activation of the spatial patterning pathways does not alter the timing of VPC fate specification [4, 5]. The heterochronic genes, including the microRNA lin-4 and its target lin-14, constitute a temporal control mechanism used in different contexts [6-8]. We find that lin-4 specifically controls the activity of LIN-12/Notch through lin-14, but not other known targets, and that persistent lin-14 blocks LIN-12 activity without interfering with the key events of LIN-12/Notch signal transduction. In the L2 stage, there is sufficient lin-14 activity to inhibit constitutive lin-12. Our results suggest that lin-4 and lin-14 contribute to spatial patterning through temporal gating of LIN-12. We propose that in the L2 stage, lin-14 sets a high threshold for LIN-12 activation to help prevent premature activation of LIN-12 by ligands expressed in other cells in the vicinity, thereby contributing to the precision and robustness of VPC fate patterning.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.