Evidence map›Paper›PMID 20950703›Full record

ReviewSeminars in cell & developmental biology2011

Regulation of sodium channel activity by phosphorylation.

Todd Scheuer

Abstract readReview
In one paragraph

Review in Seminars in cell & developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 107 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Cytoskeletal scaffolding of NaCurrent opinion in cell biology · 2025
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Inhibition of the GSK3β/Nav1.6 complex suppresses early-stage Alzheimer's hyperexcitability.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  10. Article
  11. 14-3-3 promotes sarcolemmal expression of cardiac CaProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Review
  13. Article
  14. Article
  15. Trifunctional Saxitoxin Conjugates for Covalent Labeling of Voltage-Gated Sodium Channels.Chembiochem : a European journal of chemical biology · 2023
    Article
  16. Article
  17. Modulation of potassium conductances optimizes fidelity of auditory information.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Article
  19. Article
  20. Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Todd ScheuerDepartment of Pharmacology, University of Washington School of Medicine, Seattle, WA 98195-7280, United States. scheuer@u.washington.edu
University of Washington · US

Funding

Sodium Channel Phosphorylation in Normal and Epileptic BrainR21NS064428 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SCHEUER, TODD, TRIMMER, JAMES S · 2008 to 2009
$382k
NINDS NIH HHS NS64428NINDS NIH HHS R21 NS064428
6 · The paper itself

Abstract

Voltage-gated sodium channels carry the major inward current responsible for action potential depolarization in excitable cells as well as providing additional inward current that modulates overall excitability. Both their expression and function is under tight control of protein phosphorylation by specific kinases and phosphatases and this control is particular to each type of sodium channel. This article examines the impact and mechanism of phosphorylation for isoforms where it has been studied in detail in an attempt to delineate common features as well as differences.

Indexed as

AnimalsHumansPhosphorylationProtein FoldingProtein IsoformsProtein SubunitsSodium ChannelsProtein IsoformsProtein SubunitsSodium Channels

Identifiers

PMID20950703
PMCPMC3423337
OpenAlexW1999980742

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.