ArticleNeuroImage2011
Genetics of white matter development: a DTI study of 705 twins and their siblings aged 12 to 29.
Article in NeuroImage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 141 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
141 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- White matter microstructure in children and adolescents with ADHD.NeuroImage. Clinical · 2022Pooled it
- Continuity of genetic and environmental influences on cognition across the life span: a meta-analysis of longitudinal twin and adoption studies.Psychological bulletin · 2014Pooled it
- Genetic and environmental influences on neuroimaging phenotypes: a meta-analytical perspective on twin imaging studies.Twin research and human genetics : the official journal of the International Society for Twin Studies · 2012Pooled it
- Genetic and environmental influence on white matter: insight from an Italian twin population study.Frontiers in human neuroscience · 2026Article
- Hemispheric Asymmetry in the Genetic Overlap between Schizophrenia and White Matter Microstructure.Cyborg and bionic systems (Washington, D.C.) · 2026Article
- Socioeconomic context influences the heritability of child cortical structure.Communications biology · 2025Article
- Socioeconomic context influences the heritability of child cortical structure.medRxiv : the preprint server for health sciences · 2025Article
- The cellular associates of late life changes in white matter microstructure.bioRxiv : the preprint server for biology · 2025Article
- Task-based functional connectivity in infants after exposure to regular white noise during natural sleep measured by fNIRS.Scientific reports · 2025Article
- A multisite validation of brain white matter pathways of resilience to chronic back pain.eLife · 2024Article
- Brain white matter pathways of resilience to chronic back pain: a multisite validation.bioRxiv : the preprint server for biology · 2024Article
- Differences in educational opportunity predict white matter development.Developmental cognitive neuroscience · 2024Article
- Modeling brain sex in the limbic system as phenotype for female-prevalent mental disorders.Biology of sex differences · 2024Article
- Topological state-space estimation of functional human brain networks.PLoS computational biology · 2024Article
- White matter and literacy: A dynamic system in flux.Developmental cognitive neuroscience · 2024Article
- Socioeconomic status moderates neural markers of cognitive reappraisal across preschool.Biological psychology · 2024Article
- TOPOLOGICAL LEARNING FOR BRAIN NETWORKS.The annals of applied statistics · 2023Article
- Associations between socioeconomic status and white matter microstructure in children: indirect effects via obesity and cognition.medRxiv : the preprint server for health sciences · 2023Article
- Genetic and Environmental Variation in Continuous Phenotypes in the ABCD Study®.Behavior genetics · 2023Article
- Genetic underpinnings of brain structural connectome for young adults.Journal of the American Statistical Association · 2023Article
81 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
White matter microstructure is under strong genetic control, yet it is largely unknown how genetic influences change from childhood into adulthood. In one of the largest brain mapping studies ever performed, we determined whether the genetic control over white matter architecture depends on age, sex, socioeconomic status (SES), and intelligence quotient (IQ). We assessed white matter integrity voxelwise using diffusion tensor imaging at high magnetic field (4-Tesla), in 705 twins and their siblings (age range 12-29; 290 M/415 F). White matter integrity was quantified using a widely accepted measure, fractional anisotropy (FA). We fitted gene-environment interaction models pointwise, to visualize brain regions where age, sex, SES and IQ modulate heritability of fiber integrity. We hypothesized that environmental factors would start to outweigh genetic factors during late childhood and adolescence. Genetic influences were greater in adolescence versus adulthood, and greater in males than in females. Socioeconomic status significantly interacted with genes that affect fiber integrity: heritability was higher in those with higher SES. In people with above-average IQ, genetic factors explained over 80% of the observed FA variability in the thalamus, genu, posterior internal capsule, and superior corona radiata. In those with below-average IQ, however, only around 40% FA variability in the same regions was attributable to genetic factors. Genes affect fiber integrity, but their effects vary with age, sex, SES and IQ. Gene-environment interactions are vital to consider in the search for specific genetic polymorphisms that affect brain integrity and connectivity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.