ReviewNeuropsychologia2011
Abnormal structure or function of the amygdala is a common component of neurodevelopmental disorders.
Review in Neuropsychologia, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07098156 (Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals), which is not on this map. Cited by 106 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroanatomical Differences Associated With Anorexia Nervosa and Masking Behaviour in Autistic Individuals
Who cites it
106 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Systematic Review and Meta-analysis of Neuroimaging in Oppositional Defiant Disorder (ODD) and Conduct Disorder (CD) Taking Attention-Deficit Hyperactivity Disorder (ADHD) Into Account.Neuropsychology review · 2016Pooled it
- Posttraumatic stress disorder is associated with Alzheimer's disease-relevant molecular alterations in the basolateral amygdala of older Veterans.Neurobiology of aging · 2026Article
- The Earliest Impressions: A Systematic Review of Early-Life Exposures on Brain Structure and Neurodevelopmental Outcomes.bioRxiv : the preprint server for biology · 2026Article
- Neonatal amygdala microstructure and structural connectivity are associated with autistic traits at 2 years of age.Developmental cognitive neuroscience · 2026Article
- Epilepsy and amygdalar enlargement: cause or consequence?Arquivos de neuro-psiquiatria · 2026Review
- Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring.Molecular psychiatry · 2026Article
- Serotonin receptor 4 in the ventral CA3 regulates agomelatine-induced anxiolytic-like behaviors.Acta pharmacologica Sinica · 2026Article
- Inflammatory mechanisms contribute to long-term cognitive deficits induced by perinatal asphyxia via interleukin-1.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Machine-learning classification of children and adolescents with ASD using resting-state frequency-specific intrinsic activity.Frontiers in neuroscience · 2026Article
- Amygdalar and hippocampal volume loss in limbic-predominant age-related TDP-43 encephalopathy.Brain : a journal of neurology · 2025Article
- Directional flow of brain connections and neurodevelopmental outcomes in healthy full-term newborns.Neuroscience letters · 2025Article
- Mef2c Controls Postnatal Callosal Axon Targeting by Regulating Sensitivity to Ephrin Repulsion.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neuroanatomical associations with autistic characteristics in those with acute anorexia nervosa and weight-restored individuals.Psychological medicine · 2025Article
- Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume.Molecular autism · 2025Article
- Article
- Early childhood stress and amygdala structure in children and adolescents with neurodevelopmental disorders.Brain structure & function · 2025Article
- Microglia Morphology in the Developing Primate Amygdala and Effects of Early Life Stress.eNeuro · 2025Article
- Triangular Causality Among Pulmonary Hypertension, Sleep Disorders, and Brain Structure at the Genetic Level: A Mendelian Randomization Study Focused on the Lung-Brain Axis.Nature and science of sleep · 2025Article
- Translational Insights From Cell Type Variation Across Amygdala Subnuclei in Rhesus Monkeys and Humans.The American journal of psychiatry · 2024Article
- The human social cognitive network contains multiple regions within the amygdala.Science advances · 2024Article
46 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The amygdala, perhaps more than any other brain region, has been implicated in numerous neuropsychiatric and neurodevelopmental disorders. It is part of a system initially evolved to detect dangers in the environment and modulate subsequent responses, which can profoundly influence human behavior. If its threshold is set too low, normally benign aspects of the environment are perceived as dangers, interactions are limited, and anxiety may arise. If set too high, risk taking increases and inappropriate sociality may occur. Given that many neurodevelopmental disorders involve too little or too much anxiety or too little of too much social interaction, it is not surprising that the amygdala has been implicated in many of them. In this chapter, we begin by providing a brief overview of the phylogeny, ontogeny, and function of the amygdala and then appraise data from neurodevelopmental disorders which suggest amygdala dysregulation. We focus on neurodevelopmental disorders where there is evidence of amygdala dysregulation from postmortem studies, structural MRI analyses or functional MRI. However, the results are often disparate and it is not totally clear whether this is due to inherent heterogeneity or differences in methodology. Nonetheless, the amygdala is a common site for neuropathology in neurodevelopmental disorders and is therefore a potential target for therapeutics to alleviate associated symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.