ArticleReproductive biology and endocrinology : RB&E2010
Transforming growth factor beta family expression at the bovine feto-maternal interface.
Article in Reproductive biology and endocrinology : RB&E, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 33 citations in OpenAlex.
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- Uterine Foxl2 regulates the adherence of the Trophectoderm cells to the endometrial epithelium.Reproductive biology and endocrinology : RB&E · 2018Article
- Role of activins in embryo implantation and diagnosis of ectopic pregnancy: a review.Reproductive biology and endocrinology : RB&E · 2014Article
- Delineating the prime mover action of progesterone for endometrial receptivity in primates.The Indian journal of medical research · 2014Review
- Differential neutrophil gene expression in early bovine pregnancy.Reproductive biology and endocrinology : RB&E · 2013Article
- Bovine trophoblastic cell differentiation and binucleation involves enhanced endogenous retrovirus element expression.Reproductive biology and endocrinology : RB&E · 2012Article
- The core mouse response to infection by neospora caninum defined by gene set enrichment analyses.Bioinformatics and biology insights · 2012Article
- Evidence of inhibin/activin subunit betaC and betaE synthesis in normal human endometrial tissue.Reproductive biology and endocrinology : RB&E · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndometrial remodelling is necessary for implantation in all mammalian species. The TGF beta super-family plays a crucial role in this event in humans and mice. However, the role of TGF beta super-family members during implantation is still unclear in ruminants. In the present study, the spacio-temporal expression of TGF beta super-family members including activin was explored in bovine trophoblasts and endometrial tissue during the peri-implantation period in order to elucidate whether it is essential for promoting cell proliferation at the implantation site.
methodsGene expression in the fetal membrane and endometrium of the gravid and non-gravid horn around Day 35 of gestation were analyzed with a custom-made oligo-microarray in cattle. The expression of activin and its related genes was also analyzed with quantitative RT-PCR. Activin-like activity in trophoblastic tissue and BT-1 cells was examined using a fibroblast cell proliferation test and Western blotting.
resultsThe expression of various TGF beta super-family related genes including activin was detected in trophoblasts and the endometrium in cattle. The most intensive activin expression was found in the gravid horn endometrium, and rather intense expression was detected in the non-gravid trophoblastic tissue. Extracts from the fetal membrane including trophoblasts and purified activin both stimulated fibroblast proliferation effectively, and activin was immunologically detected in BT-1 cells, which have trophoblastic features.
conclusionsSpecific expression of the activin gene (gene name: inhibin beta A) was found in the gravid horn endometrium during peri-implantation. An activin-like molecule, which was derived from the endometrium and trophoblasts, stimulated the proliferation of fibroblast cells. These results suggested that as in other species, the activity of TGF beta super-family members including activin-like molecules plays a pivotal role in endometrial remodelling, which is an essential process in implantation and placentogenesis during the peri-implantation period in cattle.
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