ArticleInternational journal of cancer2011
A strategy for distinguishing optimal cancer subtypes.
Article in International journal of cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 24 citations in OpenAlex.
- Efficiency for evaluation of disease etiologic heterogeneity in case-case and case-control studies.The international journal of biostatistics · 2025Article
- Improve the model of disease subtype heterogeneity by leveraging external summary data.PLoS computational biology · 2023Article
- Utility of Continuous Disease Subtyping Systems for Improved Evaluation of Etiologic Heterogeneity.Cancers · 2022Article
- Evidence for Etiologic Subtypes of Breast Cancer in the Carolina Breast Cancer Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2019Article
- Epidemiology of Moderate Alcohol Consumption and Breast Cancer: Association or Causation?Cancers · 2018Review
- Examining the common aetiology of serous ovarian cancers and basal-like breast cancers using double primaries.British journal of cancer · 2017Article
- Defining Cancer Subtypes With Distinctive Etiologic Profiles: An Application to the Epidemiology of Melanoma.Journal of the American Statistical Association · 2017Article
- Statistical methods for studying disease subtype heterogeneity.Statistics in medicine · 2016Article
- Integration of molecular pathology, epidemiology and social science for global precision medicine.Expert review of molecular diagnostics · 2016Review
- Identifying Etiologically Distinct Sub-Types of Cancer: A Demonstration Project Involving Breast Cancer.Cancer medicine · 2015Article
- Proceedings of the second international molecular pathological epidemiology (MPE) meeting.Cancer causes & control : CCC · 2015Article
- Etiologic field effect: reappraisal of the field effect concept in cancer predisposition and progression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Review
- Review
- A conceptual and methodological framework for investigating etiologic heterogeneity.Statistics in medicine · 2013Article
- Null association between histology of first and second primary malignancies in men with bilateral testicular germ cell tumors.American journal of epidemiology · 2013Article
- Molecular pathological epidemiology of epigenetics: emerging integrative science to analyze environment, host, and disease.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2013Review
- Interdisciplinary education to integrate pathology and epidemiology: towards molecular and population-level health science.American journal of epidemiology · 2012Article
- Aspirin as adjuvant therapy for colorectal cancer--reinterpreting paradigms.Nature reviews. Clinical oncology · 2012Review
- Age-associated gene expression in normal breast tissue mirrors qualitative age-at-incidence patterns for breast cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2012Article
- Detecting and exploiting etiologic heterogeneity in epidemiologic studies.American journal of epidemiology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Much attention is directed currently to identifying subtypes of cancers that are genetically and clinically distinct. The expectation is that subtyping on the basis of somatic genomic characteristics will supplant traditional pathological subtypes with respect to relevance for targeted therapies and clinical course. Less attention has been paid to the goal of validating subtypes on the basis of the distinctiveness of their etiologies. In this article it is shown that studies of individuals with double primary malignancies provide uniquely valuable information for establishing the etiologic distinctiveness of candidate tumor subtypes. Studies of double primaries have the potential to definitively rank candidate taxonomic systems with respect to their etiological relevance by determining which subtypes are most highly correlated in the double primaries. The concept is illustrated with data from studies of the concordance of estrogen and progestin status in bilateral breast cancers, where it is shown that double primaries are much more likely to be concordant with respect to estrogen receptor (ER) status than for PR status. The high concordance of ER status is consistent with a growing literature demonstrating the etiologic distinctiveness of ER+ and ER- tumors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.