Evidence map›Paper›PMID 20949198›Full record

ArticleLab on a chip2011

Self-assembled magnetic filter for highly efficient immunomagnetic separation.

David Issadore, Huilin Shao, Jaehoon Chung, Andita Newton, Mikael Pittet, Ralph Weissleder, Hakho Lee

Open access · greenAbstract readEvaluation Study
In one paragraph

Article in Lab on a chip, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Article
  3. Hydrodynamics in Cell Studies.Chemical reviews · 2018
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Microfluidic blood cell sorting: now and beyond.Small (Weinheim an der Bergstrasse, Germany) · 2014
    Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. A magnetic Gram stain for bacterial detection.Angewandte Chemie (International ed. in English) · 2012
    Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

David IssadoreCenter for Systems Biology, Massachusetts General Hospital, 185 Cambridge St, CPZN 5206, Boston, MA 02114, USA.
Huilin Shao
Jaehoon Chung
Andita Newton
Mikael Pittet
Ralph Weissleder
Hakho Lee
Center for Systems Biology · USMassachusetts General Hospital · US

Funding

TREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2005 to 2009
$20.5M
Translational Program of Excellence in NanotechnologyU01HL080731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2005 to 2009
$14.9M
Training Grant in Molecular Imaging Research (MGH/HMS)T32CA079443 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2000 to 2025
$10.1M
Magnetic nanoswitches for sensing biomoleculesR01EB004626 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI WEISSLEDER, MD, PHD, RALPH · 2004 to 2012
$3.2M
NCI NIH HHS T32 CA079443NCI NIH HHS T32-CA79443NCI NIH HHS U54 CA119349NCI NIH HHS U54-CA119349NHLBI NIH HHS U01 HL080731NHLBI NIH HHS U01-HL080731NIBIB NIH HHS 2R01-EB004626NIBIB NIH HHS R01 EB004626
6 · The paper itself

Abstract

We have developed a compact and inexpensive microfluidic chip, the self-assembled magnetic filter, to efficiently remove magnetically tagged cells from suspension. The self-assembled magnetic filter consists of a microfluidic channel built directly above a self-assembled NdFeB magnet. Micrometre-sized grains of NdFeB assemble to form alternating magnetic dipoles, creating a magnetic field with a very strong magnitude B (from the material) and field gradient ▽B (from the configuration) in the microfluidic channel. The magnetic force imparted on magnetic beads is measured to be comparable to state-of-the-art microfabricated magnets, allowing for efficient separations to be performed in a compact, simple device. The efficiency of the magnetic filter is characterized by sorting non-magnetic (polystyrene) beads from magnetic beads (iron oxide). The filter enriches the population of non-magnetic beads to magnetic beads by a factor of >10(5) with a recovery rate of 90% at 1 mL h(-1). The utility of the magnetic filter is demonstrated with a microfluidic device that sorts tumor cells from leukocytes using negative immunomagnetic selection, and concentrates the tumor cells on an integrated membrane filter for optical detection.

Indexed as

AnimalsCell Line, TumorEquipment DesignHumansImmunomagnetic SeparationLeukocytesMiceMicrofluidic Analytical Techniques

Identifiers

PMID20949198
PMCPMC3005961
OpenAlexW2103505760

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.