ArticlePloS one2010
Differentiation of the endometrial macrophage during pregnancy in the cow.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 88 citations in OpenAlex.
- Regulation of the maternal immune system during early bovine pregnancy.Reproduction & fertility · 2026Review
- Compartment-specific immune responses to BoAHV-1 transplacental infection in late gestation.Frontiers in veterinary science · 2026Article
- Progesterone-mediated immunomodulation in ruminant early pregnancy: mechanisms and implications for bovine fertility.Veterinary research communications · 2025Review
- A bovine 3D endometrium-on-a-chip reveals the role of conceptus-derived proteins, CAPG and PDI, in conceptus-endometrial communication.Biology of reproduction · 2025Article
- Expression of MHC I Isoforms in Bovine Placentomes: Impact of Cloning.Veterinary sciences · 2025Article
- Exploring the Potential Regulatory Mechanisms of Mitophagy in Ischemic Cardiomyopathy.International journal of general medicine · 2025Article
- Function of immune cells and effector molecules of the innate immune system in the establishment and maintenance of pregnancy in mammals - A review.Animal bioscience · 2024Article
- Superior antitumor immune response achieved with proton over photon immunoradiotherapy is amplified by the nanoradioenhancer NBTXR3.Journal of nanobiotechnology · 2024Article
- AIM2 fosters lung adenocarcinoma immune escape by modulating PD-L1 expression in tumor-associated macrophages via JAK/STAT3.Human vaccines & immunotherapeutics · 2023Article
- Dissection of key factors correlating with H5N1 avian influenza virus driven inflammatory lung injury of chicken identified by single-cell analysis.PLoS pathogens · 2023Article
- An immune indicator based on BTK and DPEP2 identifies hot and cold tumors and clinical treatment outcomes in lung adenocarcinoma.Scientific reports · 2023Article
- Transcriptomic Establishment of Pig Macrophage Polarization Signatures.Current issues in molecular biology · 2023Article
- Whole-transcriptome analysis reveals virulence-specific pathogen-host interactions at the placenta in bovine neosporosis.Frontiers in immunology · 2023Article
- Article
- The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats.Toxicology and applied pharmacology · 2021Article
- Macrophages in bovine term placenta: An ultrastructural and molecular study.Reproduction in domestic animals = Zuchthygiene · 2021Article
- Bovine Immunology: Implications for Dairy Cattle.Frontiers in immunology · 2021Review
- Identification of Pathways Associated with Placental Adaptation to Maternal Nutrient Restriction in Sheep.Genes · 2020Article
- Selected Uterine Immune Events Associated With the Establishment of Pregnancy in the Dog.Frontiers in veterinary science · 2020Article
- Dpep2 Emerging as a Modulator of Macrophage Inflammation Confers Protection Against CVB3-Induced Viral Myocarditis.Frontiers in cellular and infection microbiology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe presence of conceptus alloantigens necessitates changes in maternal immune function. One player in this process may be the macrophage. In the cow, there is large-scale recruitment of macrophages expressing CD68 and CD14 to the uterine endometrium during pregnancy. METHODOLOGY/PRINCIPAL
findingsIn the present study, the function of endometrial macrophages during pregnancy was inferred by comparison of the transcriptome of endometrial CD14(+) cells isolated from pregnant cows as compared to that of blood CD14(+) cells. The pattern of gene expression was largely similar for CD14(+) cells from both sources, suggesting that cells from both tissues are from the monocyte/macrophage lineage. A total of 1,364 unique genes were differentially expressed, with 680 genes upregulated in endometrial CD14(+) cells as compared to blood CD14(+) cells and with 674 genes downregulated in endometrial CD14(+) cells as compared to blood CD14(+) cells. Twelve genes characteristic of M2 activated macrophages (SLCO2B1, GATM, MRC1, ALDH1A1, PTGS1, RNASE6, CLEC7A, DPEP2, CD163, CCL22, CCL24, and CDH1) were upregulated in endometrial CD14(+) cells. M2 macrophages play roles in immune regulation, tissue remodeling, angiogenesis and apoptosis. Consistent with a role in tissue remodeling, there was over-representation of differentially expressed genes in endometrium for three ontologies related to proteolysis. A role in apoptosis is suggested by the observation that the most overrepresented gene in endometrial CD14(+) cells was GZMA.
conclusionsResults indicate that at least a subpopulation of endometrial macrophages cells differentiates along an M2 activation pathway during pregnancy and that the cells are likely to play roles in immune regulation, tissue remodeling, angiogenesis, and apoptosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.