ArticlePloS one2010
Differential genetic regulation of canine hip dysplasia and osteoarthritis.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Genome-wide association studies for canine hip dysplasia in single and multiple populations - implications and potential novel risk loci.BMC genomics · 2021Pooled it
- An interpretable machine learning framework for dog breed inference and ancestry decomposition.bioRxiv : the preprint server for biology · 2026Article
- The markers of the predictive DNA test for canine hip dysplasia may have a stronger relationship with elbow dysplasia.Heliyon · 2024Article
- NADPH Oxidase 3: Beyond the Inner Ear.Antioxidants (Basel, Switzerland) · 2024Review
- Mechanical osteoarthritis of the hip in a one medicine concept: a narrative review.BMC veterinary research · 2023Review
- Whole exome sequencing of 28 families of Danish descent reveals novel candidate genes and pathways in developmental dysplasia of the hip.Molecular genetics and genomics : MGG · 2023Article
- Prime editor-mediated correction of a pathogenic mutation in purebred dogs.Scientific reports · 2022Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Computed tomography reveals hip dysplasia in the extinct Pleistocene saber-tooth cat Smilodon.Scientific reports · 2021Article
- Evaluate the effects of serum urate level on bone mineral density: a genome-wide gene-environment interaction analysis in UK Biobank cohort.Endocrine · 2021Article
- Decellularized Porcine Cartilage Scaffold; Validation of Decellularization and Evaluation of Biomarkers of Chondrogenesis.International journal of molecular sciences · 2021Article
- Article
- Genomic Prediction of Two Complex Orthopedic Traits Across Multiple Pure and Mixed Breed Dogs.Frontiers in genetics · 2021Article
- Genome-wide association study to identify canine hip dysplasia loci in dogs.Journal of animal science and technology · 2020Article
- The association of genetic polymorphisms of bone formation genes with canine hip dysplasia.Iranian journal of veterinary research · 2020Article
- Genetic dissection of canine hip dysplasia phenotypes and osteoarthritis reveals three novel loci.BMC genomics · 2019Article
- Demography, heritability and genetic correlation of feline hip dysplasia and response to selection in a health screening programme.Scientific reports · 2019Article
- Article
- Article
- Genome-wide association study identifies loci and candidate genes for meat quality traits in Simmental beef cattle.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundCanine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA. METHODOLOGY/PRINCIPAL
findingsA total of 721 dogs, including both an association and linkage population, were genotyped. The association population included 8 pure breeds (Labrador retriever, Greyhounds, German Shepherd, Newfoundland, Golden retriever, Rottweiler, Border Collie and Bernese Mountain Dog). The linkage population included Labrador retrievers, Greyhounds, and their crosses. Of these, 366 dogs were genotyped at ∼22,000 single nucleotide polymorphism (SNP) loci and a targeted screen across 8 chromosomes with ∼3,300 SNPs was performed on 551 dogs (196 dogs were common to both sets). A mixed linear model approach was used to perform an association study on this combined association and linkage population. The study identified 4 susceptibility SNPs associated with HD and 2 SNPs associated with hip OA. CONCLUSION/SIGNIFICANCE: The identified SNPs included those near known genes (PTPRD, PARD3B, and COL15A1) reported to be associated with, or expressed in, OA in humans. This suggested that the canine model could provide a unique opportunity to identify genes underlying natural HD and hip OA, which are common and debilitating conditions in both dogs and humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.