Evidence map›Paper›PMID 20948916›Full record

ArticleCancer research and treatment2010

RNA regulation in neurologic disease and cancer.

Robert B Darnell

Open access · bronzeAbstract read
In one paragraph

Article in Cancer research and treatment, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
  2. The effects of leukocyteBMC veterinary research · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Computational tools to study RNA-protein complexes.Frontiers in molecular biosciences · 2022
    Review
  7. Article
  8. RNA Regulators in Leukemia and Lymphoma.Cold Spring Harbor perspectives in medicine · 2020
    Review
  9. Article
  10. IDH1 fine-tunes cap-dependent translation initiation.Journal of molecular cell biology · 2019
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Sequence-Based Prediction of RNA-Binding Residues in Proteins.Methods in molecular biology (Clifton, N.J.) · 2017
    Article
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Robert B DarnellHoward Hughes Medical Institute, Laboratory of Molecular Neuro-Oncology, The Rockefeller University, New York, NY, USA. darnelr@rockefeller.edu
Howard Hughes Medical Institute · US

Funding

NEUROLOGY AND THE MOLECULAR ROLE OF N-RBPS IN THE BRAINR01NS034389 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 1995 to 2016
$6.3M
Structure/function studies of RBPs in neurologic diseaseR01NS040955 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2001 to 2005
$3.3M
NINDS NIH HHS R01 NS034389NINDS NIH HHS R01 NS040955
6 · The paper itself

Abstract

The paraneoplastic neurologic diseases (PNDs) are brain degenerations that develop in the setting of clinically inapparent cancers. PNDs arise when common cancers express brain proteins, triggering an anti-tumor immune response and tumor immunity. Research on these brain-cancer proteins has revealed a new world of neuron-specific RNA binding proteins whose functions may be aberrantly used by tumor cells. Efforts to gain insight into their function has led to the development of new methods and strategies to understand RNA protein regulation in living tissues.

Indexed as

CLIPNovaParaneoplastic neurologic degenerationRNA binding proteinTumor immunity

Identifiers

PMID20948916
PMCPMC2953774
OpenAlexW2044365329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.