Evidence map›Paper›PMID 20948812›Full record

ArticleF1000 biology reports2010

An update on pathobiologic roles of anti-glycan antibodies in Guillain-Barré syndrome.

Kazim A Sheikh, Gang Zhang

Abstract read
In one paragraph

Article in F1000 biology reports, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Anti-Ganglioside Antibodies Induce Nodal and Axonal Injury via Fcγ Receptor-Mediated Inflammation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015
    Article
  4. Article
  5. Article
  6. Anti-ganglioside antibody-mediated activation of RhoA induces inhibition of neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011
    Article
  7. Passive transfer of IgG anti-GM1 antibodies impairs peripheral nerve repair.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kazim A SheikhDepartment of Neurology, University of Texas Medical School at Houston 6431 Fannin Street, Houston, TX 77030 USA.
Gang Zhang

Funding

Pathogenesis of Anti-ganglioside Antibody-Mediated NeuropathiesR01NS042888 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHEIKH, KAZIM A · 2002 to 2016
$4.1M
Biologic effects of anti-ganglisiode antibodiesR01NS054962 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI SHEIKH, KAZIM A · 2007 to 2018
$3.3M
NINDS NIH HHS R01 NS042888NINDS NIH HHS R01 NS054962
6 · The paper itself

Abstract

Anti-glycan antibodies directed against gangliosides are now considered the major immune effectors that induce damage to intact nerve fibers in some variants of the monophasic neuropathic disorders that comprise Guillain-Barré syndrome. Recent experimental studies elucidating the complexity of anti-glycan antibody-mediated pathobiologic effects on intact and injured nerves undergoing repair are discussed.

Identifiers

PMID20948812
PMCPMC2948347

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.