Trial reportEuropean journal of clinical nutrition2011
Impact of maternal diet during pregnancy and breastfeeding on infant metabolic programming: a prospective randomized controlled study.
Trial report in European journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00167700 (Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota), which is not on this map. Cited by 33 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Nutrition, Allergy, Mucosal Immunology and Intestinal Microbiota (NAMI): Pre-, Peri- and Postnatal Programming and Origins of Disease: Early Targeting the Epidemics of Allergy and Overweight
Who cites it
33 citing papers in PubMed, 6 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Probiotics for preventing gestational diabetes.The Cochrane database of systematic reviews · 2021Pooled it
- Maternal probiotic supplementation for prevention of morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2018Pooled it
- Diet or exercise, or both, for preventing excessive weight gain in pregnancy.The Cochrane database of systematic reviews · 2015Pooled it
- Antenatal dietary education and supplementation to increase energy and protein intake.The Cochrane database of systematic reviews · 2015Pooled it
- Probiotics for preventing gestational diabetes.The Cochrane database of systematic reviews · 2014Pooled it
- Interventions for preventing excessive weight gain during pregnancy.The Cochrane database of systematic reviews · 2012Pooled it
- Perinatal nutrition impacts on the functional development of the visual tract in infants.Pediatric research · 2019Trial
- Maternal dietary fibre intake results in sex-specific single-cell molecular changes in the heart of the offspring.Clinical science (London, England : 1979) · 2025Article
- Parental diet and offspring health: a role for the gut microbiome via epigenetics.Nature reviews. Gastroenterology & hepatology · 2025Review
- Probiotic Lactobacillus rhamnosus species: considerations for female reproduction and offspring health.Journal of assisted reproduction and genetics · 2024Review
- Maturational patterns of the infant gut mycobiome are associated with early-life body mass index.Cell reports. Medicine · 2023Article
- Mode of Neonatal Delivery Influences the Nutrient Composition of Human Milk: Results From a Multicenter European Cohort of Lactating Women.Frontiers in nutrition · 2022Article
- Changes in diet from pregnancy to one year after birth: a longitudinal study.BMC pregnancy and childbirth · 2021Article
- Identification of Critical Windows of Metabolic Programming of Metabolism and Lung Function in Male Offspring of Obese Dams.Clinical and translational science · 2020Article
- Maternal Anthropometric Factors and Circulating Adipokines as Predictors of Birth Weight and Length.International journal of environmental research and public health · 2020Article
- Microbiota Composition of Breast Milk from Women of Different Ethnicity from the Manawatu-Wanganui Region of New Zealand.Nutrients · 2020Article
- Improving pregnant women's diet and physical activity behaviours: the emergent role of health identity.BMC pregnancy and childbirth · 2020Article
- Effects of High-Fat Diet and Exercise Intervention on the Metabolism Regulation of Infant Mice.BioMed research international · 2020Article
- Characterization, the Antioxidant and Antimicrobial Activity of Exopolysaccharide Isolated from Poultry Origin Lactobacilli.Probiotics and antimicrobial proteins · 2019Article
- Relationship between the lipid composition of maternal plasma and infant plasma through breast milk.Metabolomics : Official journal of the Metabolomic Society · 2019Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesTo evaluate the impact of maternal diet and intensive dietary counselling during pregnancy and breastfeeding on the infant's metabolic status. SUBJECTS/
methodsAt the first trimester of pregnancy, 256 women were randomized into a control/placebo group and two dietary counselling groups (diet/probiotics and diet/placebo). The counselling, with double-blind randomization to probiotics (Lactobacillus rhamnosus GG and Bifidobacterium lactis) or placebo, targeted excessive saturated fat and low fibre consumption. Maternal diet was evaluated repeatedly during pregnancy and postpartum by means of 3 days' food diaries. Metabolic markers, serum 32-33 split and intact proinsulin, leptin/adiponectin ratio, skinfold thickness and waist circumference were measured of 194 healthy infants at the age of 6 months, and the high levels were taken to mirror adverse metabolic status.
resultsThe proportion of infants with a high 32-33 split proinsulin was significantly lower in dietary counselling with probiotics (n = 6/62, 9.7%) or placebo (n = 7/69, 10.1%) compared with the control/placebo group (n = 17/63, 27.0%). The high split proinsulin was associated with larger skinfold thickness, waist circumference and higher leptin/adiponectin ratio in the infants (P < 0.05). With respect to maternal diet during pregnancy, the highest and lowest tertiles of fat intake increased the infant's risk of high split proinsulin, whereas those of butter associated correspondingly with the infant's waist circumference. Further, breastfed infants showed a reduced risk of high split proinsulin and leptin/adiponectin ratio compared with formula-fed infants.
conclusionsModification of maternal diet during pregnancy and breastfeeding may benefit infant metabolic health. High split proinsulin reflects adverse metabolic status in infancy, which can be improved by early dietary counselling.
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Registered trials
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