ReviewAmerican journal of hypertension2011
Recent findings in the genetics of blood pressure and hypertension traits.
Review in American journal of hypertension, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Association of Polymorphisms in the Atrial Natriuretic Factor Gene with the Risk of Essential Hypertension: A Systematic Review and Meta-Analysis.International journal of environmental research and public health · 2016Pooled it
- Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci.American journal of human genetics · 2014Pooled it
- Polygenic risk scores predict blood pressure changes independent of dietary intervention: a secondary analysis of the NUPRESS trial.European journal of nutrition · 2026Trial
- Discovery of phenotypic networks from genotypic association studies with application to obesity.International journal of data mining and bioinformatics · 2015Trial
- Trial
- Gene panels to help identify subgroups at high and low risk of coronary heart disease among those randomized to antihypertensive treatment: the GenHAT study.Pharmacogenetics and genomics · 2012Trial
- Several lipid-related gene polymorphisms interact with overweight/obesity to modulate blood pressure levels.International journal of molecular sciences · 2012Trial
- Population molecular genetics in Brazil: From genomic databases and research to the implementation of precision medicine.Journal of community genetics · 2025Review
- Whole genome sequence analysis of apparent treatment resistant hypertension status in participants from the Trans-Omics for Precision Medicine program.Frontiers in genetics · 2023Article
- A genome-wide association study identifies a novel candidate locus at the DLGAP1 gene with susceptibility to resistant hypertension in the Japanese population.Scientific reports · 2021Article
- Genomics of disease risk in globally diverse populations.Nature reviews. Genetics · 2019Review
- Beliefs about the causes of hypertension and associations with pro-health behaviors.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2018Article
- Integrative Bioinformatics Approaches for Identification of Drug Targets in Hypertension.Frontiers in cardiovascular medicine · 2018Article
- Association of genetic variation with blood pressure traits among East Africans.Clinical genetics · 2017Article
- Rare variants in fox-1 homolog A (RBFOX1) are associated with lower blood pressure.PLoS genetics · 2017Article
- Genome-wide study of resistant hypertension identified from electronic health records.PloS one · 2017Article
- In vitro application of ribonucleases: comparison of the effects on mRNA and miRNA stability.BMC research notes · 2015Article
- Mapping of a blood pressure QTL on chromosome 17 in American Indians of the strong heart family study.BMC cardiovascular disorders · 2014Article
- Lack of family-based association between common variations in WNK1 and blood pressure level.Medical science monitor : international medical journal of experimental and clinical research · 2014Article
- CYP3A5 polymorphism, amlodipine and hypertension.Journal of human hypertension · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We provide an overview of ongoing discovery efforts in the genetics of blood pressure (BP) and hypertension (HTN) traits. Two large genome-wide association meta-analyses of individuals of European descent were recently published, revealing ~13 new loci for BP traits. Only two of these loci harbor genes in a pathway known to affect BP (CYP17A1 and NPPA/NPPB). Functional variants in these loci are still unknown. Few genome-wide association studies (GWAS) of complex diseases have been published from non-European populations. The study of populations with different evolutionary history and linkage disequilibrium (LD) structure, such as individuals of African ancestry, may provide an opportunity to further narrow these regions to identify the causal gene(s). Several collaborative efforts toward discovery of low-frequency variants and copy number variation for BP traits are currently underway. As evidence for new loci for complex diseases accumulates the assessment of the epidemiologic architecture of these variants in populations assumes higher priority. The impact of public health-relevant contexts such as diet, physical activity, psychosocial factors, and aging has not been examined for most common variants associated with BP.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.