ArticlePsychosomatic medicine2011
Depression predicts elevated endothelin-1 in patients with coronary artery disease.
Article in Psychosomatic medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- The roles of exosomes in the pathogenesis and treatment of coronary heart disease with depression and/or anxiety.Brain, behavior, & immunity - health · 2025Review
- Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats.Biology · 2023Article
- Crosstalk Among NLRP3 Inflammasome, ETNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021Article
- Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.The EPMA journal · 2021Review
- From Heartbreak to Heart Disease: A Narrative Review on Depression as an Adjunct to Cardiovascular Disease.Pulse (Basel, Switzerland) · 2021Review
- Recurrent versus new-onset depressive symptoms: Relationships with biomarkers of cardiovascular health following acute coronary syndrome.Journal of psychosomatic research · 2021Article
- Effects of Curcumin on Depression and Anxiety: A Narrative Review of the Recent Clinical Data.Advances in experimental medicine and biology · 2021Review
- Depression and coronary heart disease: 2018 position paper of the ESC working group on coronary pathophysiology and microcirculation.European heart journal · 2020Article
- Two-year prognosis after acute coronary syndrome in younger patients: Association with feeling depressed in the prior year, and BDI-II score and Endothelin-1.Journal of psychosomatic research · 2017Article
- The interface of emotion and biology in myocardial ischemia: Can we progress using the traditional paradigm?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2017Article
- Associations Between Psychological Constructs and Cardiac Biomarkers After Acute Coronary Syndrome.Psychosomatic medicine · 2017Observational
- Observational
- Severe depressive symptoms are associated with elevated endothelin-1 in younger patients with acute coronary syndrome.Journal of psychosomatic research · 2014Article
- Confluence of depression and acute psychological stress among patients with stable coronary heart disease: effects on myocardial perfusion.Journal of the American Heart Association · 2014Article
- Lifetime history of depression, type 2 diabetes, and endothelial reactivity to acute stress in postmenopausal women.International journal of behavioral medicine · 2012Article
- Heartache and heartbreak--the link between depression and cardiovascular disease.Nature reviews. Cardiology · 2012Review
- "Blues" ain't good for the heart.Indian journal of psychiatry · 2011Article
- Epidemiology and treatment of depression in patients with chronic medical illness.Dialogues in clinical neuroscience · 2011Review
- The 'perfect storm' and acute coronary syndrome onset: do psychosocial factors play a role?Progress in cardiovascular diseasesReview
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Authors and funding
4 authors.
Funding
Abstract
objectiveTo examine the relationship of depression severity to circulating endothelin-1 (ET-1), which has previously been linked to plaque rupture and postacute coronary syndrome (ACS) survival. Depression carries an independent two- to four-fold increased risk of early morbidity and mortality after ACS. The pathway(s) linking depression to event-free survival remains to be determined.
methodsPatients with documented history of coronary artery disease (n = 101) provided a resting morning blood sample that was assayed for ET-1, and they completed the Beck Depression Inventory (BDI). ET-1 was treated as a log-transformed continuous variable (logET-1), and as a dichotomous variable using a post-ACS risk threshold previously reported (≥1.16 fmol/mL).
resultsBDI score was related to logET-1 in both unadjusted and adjusted models. In addition, unadjusted and adjusted logistic regression models with dichotomous ET-1 revealed that, for each point increase in BDI score, there was approximately a 14% increased likelihood of being at or above ET-1 risk threshold. Secondary logistic regression models demonstrated a >3.5-fold likelihood of being at or above this risk threshold in association with a BDI score of ≥10.
conclusionsDepression symptom severity predicts ET-1 elevation that has previously been linked to post-ACS survival, with the greatest risk of elevation among those patients with worse depression symptoms. This link may identify a vulnerability to triggered ACS and poorer survival associated with depression. Future research should establish whether the observed relationship of depressive symptoms to ET-1 level mediates the link between depression and survival.
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