ArticleHuman molecular genetics2011
Dystrophin conferral using human endothelium expressing HLA-E in the non-immunosuppressive murine model of Duchenne muscular dystrophy.
Article in Human molecular genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Can Human Embryonic Stem Cell-Derived Stromal Cells Serve a Starting Material for Myoblasts?Stem cells international · 2017Article
- Xenogeneic-free defined conditions for derivation and expansion of human embryonic stem cells with mesenchymal stem cells.Regenerative therapy · 2015Article
- Derivation of human decidua-like cells from amnion and menstrual blood.Scientific reports · 2014Article
- Placenta to cartilage: direct conversion of human placenta to chondrocytes with transformation by defined factors.Molecular biology of the cell · 2012Article
- Allogeneic amniotic membrane-derived mesenchymal stromal cell transplantation in a porcine model of chronic myocardial ischemia.Journal of stem cells & regenerative medicine · 2012Article
- Glycome diagnosis of human induced pluripotent stem cells using lectin microarray.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human leukocyte antigen (HLA)-E is a non-classical major histocompatibility complex class I (Ib) molecule, which plays an important role in immunosuppression. In this study, we investigated the immunomodulating effect of HLA-E in a xenogeneic system, using human placental artery-derived endothelial (hPAE) cells expressing HLA-E in a mouse model. In vitro cell lysis analysis by primed lymphocytes in combination with siRNA transfection showed that HLA-E is necessary for inhibition of the immune response. Similarly, in vivo cell implantation analysis with siRNA-mediated down-regulation of HLA-E demonstrates that HLA-E is involved in immunosuppression. As hPAE cells efficiently transdifferentiate into myoblasts/myocytes in vitro, we transplanted the cells into mdx mice, a model of Duchenne muscular dystrophy. hPAE cells conferred dystrophin to myocytes of the 'immunocompetent' mdx mice with extremely high efficiency. These findings suggest that HLA-E-expressing cells with a myogenic potential represent a promising source for cell-based therapy of patients with muscular dystrophy.
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Registered trials
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