ArticleStructure (London, England : 1993)2010
Structural insight into serine protease Rv3671c that Protects M. tuberculosis from oxidative and acidic stress.
Article in Structure (London, England : 1993), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Cell wall remodeling-dependent morphotype switch inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Urotensin II system contributes to ischemic acute kidney injury in neonatal pigs.Renal failure · 2025Article
- An unusual genetic switch controlsbioRxiv : the preprint server for biology · 2025Article
- Iron-restricted Mycobacterium tuberculosis exports pathogenicity factors packed in extracellular vesicles.PloS one · 2025Article
- Attenuated but immunostimulatory Mycobacterium tuberculosis variant bovis strain Ravenel shows variation in T cell epitopes.Scientific reports · 2023Article
- Expression of recombinant protease MarP from Mycobacterium tuberculosis in Pichia pastoris and its effect on human monocytes.Biotechnology letters · 2021Article
- The Cell Wall Hydrolytic NlpC/P60 Endopeptidases in Mycobacterial Cytokinesis: A Structural Perspective.Cells · 2019Review
- Identification of Compounds with pH-Dependent Bactericidal Activity against Mycobacterium tuberculosis.ACS infectious diseases · 2019Article
- Distributions of Extracellular Peptidases Across Prokaryotic Genomes Reflect Phylogeny and Habitat.Frontiers in microbiology · 2019Article
- Two New Secreted Proteases Generate a Casein-Derived Antimicrobial Peptide inFrontiers in microbiology · 2018Article
- Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).Biochemistry · 2017Article
- Article
- A Mycobacterium avium subsp. paratuberculosis Predicted Serine Protease Is Associated with Acid Stress and Intraphagosomal Survival.Frontiers in cellular and infection microbiology · 2016Article
- Mycobacterial genes essential for the pathogen's survival in the host.Immunological reviews · 2015Review
- Soluble expression, purification, and characterization of active recombinant human tissue plasminogen activator by auto-induction in E. coli.BMC biotechnology · 2015Article
- Target-based screen against a periplasmic serine protease that regulates intrabacterial pH homeostasis in Mycobacterium tuberculosis.ACS chemical biology · 2015Article
- Stress-triggered activation of the metalloprotease Oma1 involves its C-terminal region and is important for mitochondrial stress protection in yeast.The Journal of biological chemistry · 2014Article
- Mycobacterium tuberculosis Hip1 modulates macrophage responses through proteolysis of GroEL2.PLoS pathogens · 2014Article
- Article
- Substrate specificity of MarP, a periplasmic protease required for resistance to acid and oxidative stress in Mycobacterium tuberculosis.The Journal of biological chemistry · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Rv3671c, a putative serine protease, is crucial for persistence of Mycobacterium tuberculosis in the hostile environment of the phagosome. We show that Rv3671c is required for M. tuberculosis resistance to oxidative stress in addition to its role in protection from acidification. Structural and biochemical analyses demonstrate that the periplasmic domain of Rv3671c is a functional serine protease of the chymotrypsin family and, remarkably, that its activity increases on oxidation. High-resolution crystal structures of this protease in an active strained state and in an inactive relaxed state reveal that a solvent-exposed disulfide bond controls the protease activity by constraining two distant regions of Rv3671c and stabilizing it in the catalytically active conformation. In vitro biochemical studies confirm that activation of the protease in an oxidative environment is dependent on this reversible disulfide bond. These results suggest that the disulfide bond modulates activity of Rv3671c depending on the oxidative environment in vivo.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.