ArticleMethods in enzymology2009
Catalytic activity as a probe of native RNA folding.
Article in Methods in enzymology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Transformers in RNA structure prediction: A review.Computational and structural biotechnology journal · 2025Review
- Tracking NativeBiochemistry · 2023Article
- Measurement of ATP utilization in RNA unwinding and RNA chaperone activities by DEAD-box helicase proteins.Methods in enzymology · 2022Article
- Probing RNA-Protein Interactions and RNA Compaction by Sedimentation Velocity Analytical Ultracentrifugation.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Molecular crowding overcomes the destabilizing effects of mutations in a bacterial ribozyme.Nucleic acids research · 2015Article
- Native Purification and Analysis of Long RNAs.Methods in enzymology · 2015Article
- A kinetic and thermodynamic framework for the Azoarcus group I ribozyme reaction.RNA (New York, N.Y.) · 2014Article
- DEAD-box protein CYT-19 is activated by exposed helices in a group I intron RNA.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Folding pathways of the Tetrahymena ribozyme.Journal of molecular biology · 2014Article
- RNA catalytic activity as a probe of chaperone-mediated RNA folding.Methods in molecular biology (Clifton, N.J.) · 2014Article
- The long-range P3 helix of the Tetrahymena ribozyme is disrupted during folding between the native and misfolded conformations.Journal of molecular biology · 2013Article
- Toward a molecular understanding of RNA remodeling by DEAD-box proteins.RNA biology · 2013Review
- Kinetics of tRNA folding monitored by aminoacylation.RNA (New York, N.Y.) · 2012Article
- RNA catalysis as a probe for chaperone activity of DEAD-box helicases.Methods in enzymology · 2012Article
- The Azoarcus group I intron ribozyme misfolds and is accelerated for refolding by ATP-dependent RNA chaperone proteins.The Journal of biological chemistry · 2011Article
- ATP-dependent roles of the DEAD-box protein Mss116p in group II intron splicing in vitro and in vivo.Journal of molecular biology · 2011Article
- Enhanced specificity against misfolding in a thermostable mutant of the Tetrahymena ribozyme.Biochemistry · 2011Article
- Multiple unfolding events during native folding of the Tetrahymena group I ribozyme.Journal of molecular biology · 2010Article
- ATP utilization by a DEAD-box protein during refolding of a misfolded group I intron ribozyme.The Journal of biological chemistryArticle
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Authors and funding
3 authors.
Funding
Abstract
As RNAs fold to functional structures, they traverse complex energy landscapes that include many partially folded and misfolded intermediates. For structured RNAs that possess catalytic activity, this activity can provide a powerful means of monitoring folding that is complementary to biophysical approaches. RNA catalysis can be used to track accumulation of the native RNA specifically and quantitatively, readily distinguishing the native structure from intermediates that resemble it and may not be differentiated by other approaches. Here, we outline how to design and interpret experiments using catalytic activity to monitor RNA folding, and we summarize adaptations of the method that have been used to probe aspects of folding well beyond determination of the folding rates.
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