ArticleBMC genomics2010
Transcriptomic and functional analysis of the Anopheles gambiae salivary gland in relation to blood feeding.
Article in BMC genomics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Pooled it
- Salivary gland microbiome ofFrontiers in insect science · 2026Review
- Parasite and vector circadian clocks mediate efficient malaria transmission.Nature microbiology · 2025Article
- Anopheles gambiae lacking AgTRIO probe inefficiently on a mammalian host.Cell reports · 2024Article
- Sugar restriction and blood ingestion shape divergent immune defense trajectories in the mosquito Aedes aegypti.Scientific reports · 2023Article
- A Review on Digestive System ofInsects · 2023Review
- Impact of insecticide resistance on malaria vector competence: a literature review.Malaria journal · 2023Review
- Utility of MALDI-TOF MS for determination of species identity and blood meal sources of primary malaria vectors on the Kenyan coast.Wellcome open research · 2023Article
- Article
- Effective Oral RNA Interference (RNAi) Administration to Adult Anopheles gambiae Mosquitoes.Journal of visualized experiments : JoVE · 2022Article
- Characterization of Anopheles gambiae D7 salivary proteins as markers of human-mosquito bite contact.Parasites & vectors · 2022Article
- First evaluation of antibody responses to Culex quinquefasciatus salivary antigens as a serological biomarker of human exposure to Culex bites: A pilot study in Côte d'Ivoire.PLoS neglected tropical diseases · 2021Article
- Identification and Pilot Evaluation of Salivary Peptides fromInternational journal of molecular sciences · 2020Article
- Article
- Efficient Stereospecific HMagnetochemistry (Basel, Switzerland) · 2018Article
- Genome-wide transcriptional analyses in Anopheles mosquitoes reveal an unexpected association between salivary gland gene expression and insecticide resistance.BMC genomics · 2018Article
- Transcriptome-wide responses of adult melon thrips (Thrips palmi) associated with capsicum chlorosis virus infection.PloS one · 2018Article
- A Mucin-Like Protein of Planthopper Is Required for Feeding and Induces Immunity Response in Plants.Plant physiology · 2018Article
- Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infection in the salivary glands.Scientific reports · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe Anopheles gambiae salivary glands play a major role in malaria transmission and express a variety of bioactive components that facilitate blood-feeding by preventing platelet aggregation, blood clotting, vasodilatation, and inflammatory and other reactions at the probing site on the vertebrate host.
resultsWe have performed a global transcriptome analysis of the A. gambiae salivary gland response to blood-feeding, to identify candidate genes that are involved in hematophagy. A total of 4,978 genes were found to be transcribed in this tissue. A comparison of salivary gland transcriptomes prior to and after blood-feeding identified 52 and 41 transcripts that were significantly up-regulated and down-regulated, respectively. Ten genes were further selected to assess their role in the blood-feeding process using RNAi-mediated gene silencing methodology. Depletion of the salivary gland genes encoding D7L2, anophelin, peroxidase, the SG2 precursor, and a 5'nucleotidase gene significantly increased probing time of A. gambiae mosquitoes and thereby their capacity to blood-feed.
conclusionsThe salivary gland transcriptome comprises approximately 38% of the total mosquito transcriptome and a small proportion of it is dynamically changing already at two hours in response to blood feeding. A better understanding of the salivary gland transcriptome and its function can contribute to the development of pathogen transmission control strategies and the identification of medically relevant bioactive compounds.
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