ArticleBMC plant biology2010
Global transcript profiling of transgenic plants constitutively overexpressing the RNA-binding protein AtGRP7.
Article in BMC plant biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 63 citations in OpenAlex.
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- RNA-Binding Proteins: The Key Modulator in Stress Granule Formation and Abiotic Stress Response.Frontiers in plant science · 2022Review
- Global Survey of Alternative Splicing in Rice by Direct RNA Sequencing During Reproductive Development: Landscape and Genetic Regulation.Rice (New York, N.Y.) · 2021Article
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- The Landscape of RNA-Protein Interactions in Plants: Approaches and Current Status.International journal of molecular sciences · 2021Review
- Improved Functional Expression of Cytochrome P450s inFrontiers in bioengineering and biotechnology · 2021Article
- Different copies of SENSITIVITY TO RED LIGHT REDUCED 1 show strong subfunctionalization in Brassica napus.BMC plant biology · 2019Article
- The Plant Circadian Oscillator.Biology · 2019Review
- Beyond Transcription: Fine-Tuning of Circadian Timekeeping by Post-Transcriptional Regulation.Genes · 2018Review
- Genome-Wide Association Analyses Reveal the Importance of Alternative Splicing in Diversifying Gene Function and Regulating Phenotypic Variation in Maize.The Plant cell · 2018Article
- A Glycine-Rich RNA-Binding Protein, CsGR-RBP3, Is Involved in Defense Responses Against Cold Stress in Harvested Cucumber (Frontiers in plant science · 2018Article
- Which Plant Proteins Are Involved in Antiviral Defense? Review on In Vivo and In Vitro Activities of Selected Plant Proteins against Viruses.International journal of molecular sciences · 2017Review
- Light Regulation of Alternative Pre-mRNA Splicing in Plants.Photochemistry and photobiology · 2017Review
- Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold.Cellular and molecular life sciences : CMLS · 2016Review
- RNA around the clock - regulation at the RNA level in biological timing.Frontiers in plant science · 2015Review
- Regulation of pri-miRNA processing by the hnRNP-like protein AtGRP7 in Arabidopsis.Nucleic acids research · 2014Article
- A glycine-rich RNA-binding protein affects gibberellin biosynthesis in Arabidopsis.Molecular biology reports · 2014Article
- Plant RNA binding proteins for control of RNA virus infection.Frontiers in physiology · 2013Review
- Alternative splicing at the intersection of biological timing, development, and stress responses.The Plant cell · 2013Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe clock-controlled RNA-binding protein AtGRP7 influences circadian oscillations of its own transcript at the post-transcriptional level. To identify additional targets that are regulated by AtGRP7, transcript profiles of transgenic plants constitutively overexpressing AtGRP7 (AtGRP7-ox) and wild type plants were compared.
resultsApproximately 1.4% of the transcripts represented on the Affymetrix ATH1 microarray showed changes in steady-state abundance upon AtGRP7 overexpression. One third of the differentially expressed genes are controlled by the circadian clock, and they show a distinct bias of their phase: The up-regulated genes preferentially peak around dawn, roughly opposite to the AtGRP7 peak abundance whereas the down-regulated genes preferentially peak at the end of the day. Further, transcripts responsive to abiotic and biotic stimuli were enriched among AtGRP7 targets. Transcripts encoding the pathogenesis-related PR1 and PR2 proteins were elevated in AtGRP7-ox plants but not in plants overexpressing AtGRP7 with a point mutation in the RNA-binding domain, indicating that the regulation involves RNA binding activity of AtGRP7. Gene set enrichment analysis uncovered components involved in ribosome function and RNA metabolism among groups of genes upregulated in AtGRP7-ox plants, consistent with its role in post-transcriptional regulation.
conclusionApart from regulating a suite of circadian transcripts in a time-of-day dependent manner AtGRP7, both directly and indirectly, affects other transcripts including transcripts responsive to abiotic and biotic stimuli. This suggests a regulatory role of AtGRP7 in the output of the endogenous clock and a complex network of transcripts responsive to external stimuli downstream of the AtGRP7 autoregulatory circuit.
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Registered trials
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