ArticlePhotochemistry and photobiology
Oral feeding of pomegranate fruit extract inhibits early biomarkers of UVB radiation-induced carcinogenesis in SKH-1 hairless mouse epidermis.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 76 citations in OpenAlex.
- Pomegranate Juice and Extract Consumption Increases the Resistance to UVB-induced Erythema and Changes the Skin Microbiome in Healthy Women: a Randomized Controlled Trial.Scientific reports · 2019Trial
- P53 and the Ultraviolet Radiation-Induced Skin Response: Finding the Light in the Darkness of Triggered Carcinogenesis.Cancers · 2024Review
- Review
- Keratinocyte Carcinoma and Photoprevention: The Protective Actions of Repurposed Pharmaceuticals, Phytochemicals and Vitamins.Cancers · 2021Review
- Preventive effect of pomegranate juice against chemically induced bladder cancer: An experimental study.Heliyon · 2020Article
- An Update on the Role of Dietary Phytochemicals in Human Skin Cancer: New Insights into Molecular Mechanisms.Antioxidants (Basel, Switzerland) · 2020Review
- A Review of the Potential Benefits of Plants Producing Berries in Skin Disorders.Antioxidants (Basel, Switzerland) · 2020Review
- Whole Fruit Phytochemicals Combating Skin Damage and Carcinogenesis.Translational oncology · 2020Review
- Chemopreventive effect of pomegranate and cocoa extracts on ultraviolet radiation-induced photocarcinogenesis in SKH-1 mice.PloS one · 2020Article
- Dietary compounds and cutaneous malignant melanoma: recent advances from a biological perspective.Nutrition & metabolism · 2019Review
- Oral Photoprotection: Effective Agents and Potential Candidates.Frontiers in medicine · 2018Review
- Beneficial effects of dried pomegranate juice concentrated powder on ultraviolet B-induced skin photoaging in hairless mice.Experimental and therapeutic medicine · 2017Article
- Phytochemicals for the Prevention of Photocarcinogenesis.Photochemistry and photobiology · 2017Review
- Pomegranate for Prevention and Treatment of Cancer: An Update.Molecules (Basel, Switzerland) · 2017Review
- Mechanisms of Photoaging and Cutaneous Photocarcinogenesis, and Photoprotective Strategies with Phytochemicals.Antioxidants (Basel, Switzerland) · 2015Review
- Potential Effects of Pomegranate Polyphenols in Cancer Prevention and Therapy.Oxidative medicine and cellular longevity · 2015Review
- New Enlightenment of Skin Cancer Chemoprevention through Phytochemicals: In Vitro and In Vivo Studies and the Underlying Mechanisms.BioMed research international · 2014Review
- Pomegranate extracts and cancer prevention: molecular and cellular activities.Anti-cancer agents in medicinal chemistry · 2013Review
- Article
- Protective Effect of Punica granatum L. against Serum/Glucose Deprivation-Induced PC12 Cells Injury.Evidence-based complementary and alternative medicine : eCAM · 2013Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Pomegranate from the plant Punica granatum L. possesses strong antioxidant and anti-inflammatory properties. Recently, we have demonstrated that treatment of normal human epidermal keratinocytes with pomegranate fruit extract (PFE) inhibited UVB-mediated activation of nuclear factor kappa B (NF-κB) and mitogen activated protein kinases pathways. Here, we evaluated the effect of PFE on early biomarkers of photocarcinogenesis employing SKH-1 hairless mice. PFE was provided in drinking water (0.2%, wt/vol) to SKH-1 hairless mice for 14 days before a single UVB (180 mJ cm(-2)) irradiation. We found that oral feeding of PFE inhibited UVB-induced: (1) skin edema; (2) hyperplasia; (3) infiltration of leukocytes; (4) lipid peroxidation; (5) hydrogen peroxide generation; (6) ornithine decarboxylase (ODC) activity; and (7) ODC, cyclooxygenase-2 and proliferating cell nuclear antigen protein expression. Oral feeding of PFE enhanced repair of UVB-mediated formation of cyclobutane pyrimidine dimers (CPDs) and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG). Importantly, PFE treatment further enhanced UVB-mediated increase in tumor suppressor p53 and cyclin kinase inhibitor p21. Furthermore, oral feeding of PFE inhibited UVB-mediated: (1) nuclear translocation of NF-κB; (2) activation of IKKα; and (3) phosphorylation and degradation of IκBα. Taken together, we provide evidence that oral feeding of PFE to mice affords substantial protection from the adverse effects of UVB radiation via modulation in early biomarkers of photocarcinogenesis and provide suggestion for its photochemopreventive potential.
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