ReviewActa physiologica (Oxford, England)2011
Transcellular and paracellular pathways of transepithelial fluid secretion in Malpighian (renal) tubules of the yellow fever mosquito Aedes aegypti.
Review in Acta physiologica (Oxford, England), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 104 citations in OpenAlex.
- Voltage-gated ion channel TRP/Painless regulates the excretory function of the Malpighian tubules in larval lepidopterans.The Journal of experimental biology · 2025Article
- Proton-driven sodium secretion in a saline water animal.Scientific reports · 2024Article
- Voltage-gated ion channels are expressed in the Malpighian tubules and anal papillae of the yellow fever mosquito (Aedes aegypti), and may regulate ion transport during salt and water imbalance.The Journal of experimental biology · 2024Article
- Protein localization of aquaporins in the adult female disease vector mosquito,Frontiers in insect science · 2024Article
- Voltage-gated ion channels as novel regulators of epithelial ion transport in the osmoregulatory organs of insects.Frontiers in insect science · 2024Review
- Developmental and Nutritional Dynamics of Malpighian Tubule Autofluorescence in the Asian Tiger MosquitoInternational journal of molecular sciences · 2023Article
- The V-type HProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gene expression profiles in Malpighian tubules of the vector leafhopper Psammotettix striatus (L.) revealed regional functional diversity and heterogeneity.BMC genomics · 2022Article
- Article
- The septate junction protein Tetraspanin 2A is critical to the structure and function of Malpighian tubules inAmerican journal of physiology. Cell physiology · 2020Article
- The septate junction protein Mesh is required for epithelial morphogenesis, ion transport, and paracellular permeability in theAmerican journal of physiology. Cell physiology · 2020Article
- Receptor Characterization and Functional Activity of Pyrokinins on the Hindgut in the Adult Mosquito,Frontiers in physiology · 2020Article
- Arthropods Under Pressure: Stress Responses and Immunity at the Pathogen-Vector Interface.Frontiers in immunology · 2020Review
- The Drosophila Malpighian tubule as a model for mammalian tubule function.Current opinion in nephrology and hypertension · 2019Review
- secCl is a cys-loop ion channel necessary for the chloride conductance that mediates hormone-induced fluid secretion in Drosophila.Scientific reports · 2019Article
- Heterologous Expression ofInsects · 2019Article
- Article
- Bugs battle stress from hot blood.eLife · 2017Article
- Thermal acclimation mitigates cold-induced paracellular leak from the Drosophila gut.Scientific reports · 2017Article
- Malpighian Tubules as Novel Targets for Mosquito Control.International journal of environmental research and public health · 2017Review
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Isolated Malpighian tubules of the yellow fever mosquito secrete NaCl and KCl from the peritubular bath to the tubule lumen via active transport of Na(+) and K(+) by principal cells. Lumen-positive transepithelial voltages are the result. The counter-ion Cl(-) follows passively by electrodiffusion through the paracellular pathway. Water follows by osmosis, but specific routes for water across the epithelium are unknown. Remarkably, the transepithelial secretion of NaCl, KCl and water is driven by a H(+) V-ATPase located in the apical brush border membrane of principal cells and not the canonical Na(+), K(+) -ATPase. A hypothetical cation/H(+) exchanger moves Na(+) and K(+) from the cytoplasm to the tubule lumen. Also remarkable is the dynamic regulation of the paracellular permeability with switch-like speed which mediates in part the post-blood-meal diuresis in mosquitoes. For example, the blood meal the female mosquito takes to nourish her eggs triggers the release of kinin diuretic peptides that (i) increases the Cl(-) conductance of the paracellular pathway and (ii) assembles V(1) and V(0) complexes to activate the H(+) V-ATPase and cation/H(+) exchange close by. Thus, transcellular and paracellular pathways are both stimulated to quickly rid the mosquito of the unwanted salts and water of the blood meal. Stellate cells of the tubule appear to serve a metabolic support role, exporting the HCO(3)(-) generated during stimulated transport activity. Septate junctions define the properties of the paracellular pathway in Malpighian tubules, but the proteins responsible for the permselectivity and barrier functions of the septate junction are unknown.
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