ArticleOrganic letters2010
Computational design of a self-assembling β-peptide oligomer.
Article in Organic letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Structure-activity relationships in catalytic amyloids.Journal of inorganic biochemistry · 2026Article
- Programmable Helicity and Macrocycle Symmetry in β-Peptides via Site-Selective Thioamide Substitution.Journal of the American Chemical Society · 2025Article
- Article
- Instructed-Assembly of Small Peptides Inhibits Drug-Resistant Prostate Cancer Cells.Peptide science (Hoboken, N.J.) · 2020Article
- Catalytic peptide assemblies.Chemical Society reviews · 2018Review
- Synthesis and Self-Assembly of Bundle-Forming α-Helical Peptide-Dendron Hybrids.Biomacromolecules · 2016Article
- How special is the biochemical function of native proteins?F1000Research · 2016Review
- Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Functional characterization of a melittin analog containing a non-natural tryptophan analog.Biopolymers · 2015Article
- Implications of the small number of distinct ligand binding pockets in proteins for drug discovery, evolution and biochemical function.Bioorganic & medicinal chemistry letters · 2015Review
- 2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.The Journal of chemical physics · 2014Article
- Short peptides self-assemble to produce catalytic amyloids.Nature chemistry · 2014Article
- Article
- Article
- Computational design of a β-peptide that targets transmembrane helices.Journal of the American Chemical Society · 2011Article
- Environment- and sequence-dependence of helical type in membrane-spanning peptides composed of β3-amino acids.Organic letters · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The first computationally designed self-assembling oligomer consisting of exclusively β-amino acids (βAAs) is presented. The packing of a β-3(14) helix into coiled-coils of varying stoichiometries as a function of amino acid sequence is examined. β-Peptides with hVal repeating every third residue in the sequence appeared to have a strong propensity to pack into hexameric bundles. The designed sequence was synthesized and characterized with CD spectroscopy, NMR, and analytical ultracentrifugation, suggesting that the peptide adopts a well-folded hexameric structure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.