ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2010
Scientific imperatives, clinical implications, and theoretical underpinnings for the investigation of the relationship between genetic variables and patient-reported quality-of-life outcomes.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014Pooled it
- Meta-analysis shows clinically relevant and long-lasting deterioration in health-related quality of life after esophageal cancer surgery.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2014Pooled it
- Sex-, Age-, Lifestyle-, and Comorbidity-Specific Reference Values for Serum Cytokines in the Dutch General Population: Results From the PROFILES Registry.Cancer medicine · 2026Article
- Remote blood collection among cancer patients and age- and sex-matched controls for biomarker and genetic analyses using the PROFILES registry.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Review
- Impact of Cytokine Genes on TMD and QoL in Construction Workers.Brazilian dental journal · 2026Article
- Determinants and mediating mechanisms of quality of life and disease-specific symptoms among thyroid cancer patients: the design of the WaTCh study.Thyroid research · 2023Article
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- Measuring Clinical, Biological, and Behavioral Variables to Elucidate Trajectories of Patient-Reported Outcomes: The PROFILES Registry.Journal of the National Cancer Institute · 2022Article
- Current and Future Applications of Artificial Intelligence in Coronary Artery Disease.Healthcare (Basel, Switzerland) · 2022Review
- Article
- Genetic Variations and Health-Related Quality of Life (HRQOL): A Genome-Wide Study Approach.Cancers · 2021Article
- Genetic polymorphisms and haplotypes of BRCA1 gene associated with quality of life and survival among patients with non-small-cell lung cancer.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2020Article
- Cytokine Genetic Variants and Health-Related Quality of Life in Crohn's Disease: An Exploratory Study.Biological research for nursing · 2019Article
- The combined polymorphisms of interleukin-6-174GG genotype and interleukin-10 ATA haplotype are associated with a poor quality of life in patients with chronic hepatitis C.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2019Article
- Cytokine Gene Polymorphisms Associated With Various Domains of Quality of Life in Women With Breast Cancer.Journal of pain and symptom management · 2018Article
- Patient-Reported Outcomes in Patients with Chronic Kidney Disease and Kidney Transplant-Part 1.Frontiers in medicine · 2017Review
- Phenotypic and molecular characteristics associated with various domains of quality of life in oncology patients and their family caregivers.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2016Article
- Lessons From Large-Scale Collection of Patient-Reported Outcomes: Implications for Big Data Aggregation and Analytics.International journal of radiation oncology, biology, physics · 2016Article
- The longitudinal relationship between quality of life and survival in advanced stage cancer.Psycho-oncology · 2016Article
- Association between single-nucleotide polymorphisms in growth factor genes and quality of life in men with prostate cancer and the general population.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2015Article
Corrections and comments
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThere is emerging evidence for a genetic basis of patient-reported quality-of-life (QOL) outcomes that can ultimately be incorporated into clinical research and practice. Objectives are (1) to provide arguments for the timeliness of investigating the genetic basis of QOL given the scientific advances in genetics and patient-reported QOL research; (2) to describe the clinical implications of such investigations; (3) to present a theoretical foundation for investigating the genetic underpinnings of QOL; and (4) to describe a series of papers resulting from the GENEQOL Consortium that was established to move this work forward.
methodsDiscussion of scientific advances based on relevant literature.
resultsIn genetics, technological advances allow for increases in speed and efficiency and decreases in costs in exploring the genetic underpinnings of disease processes, drug metabolism, treatment response, and survival. In patient-based research, advances yield empirically based and stringent approaches to measurement that are scientifically robust. Insights into the genetic basis of QOL will ultimately allow early identification of patients susceptible to QOL deficits and to target care. The Wilson and Cleary model for patient-reported outcomes was refined by incorporating the genetic underpinnings of QOL.
conclusionsThis series of papers provides a path for QOL and genetics researchers to work together to move this field forward and to unravel the intricate interplay of the genetic underpinnings of patient-reported QOL outcomes. The ultimate result will be a greater understanding of the process relating disease, patient, and doctor that will have the potential to lead to improved survival, QOL, and health services delivery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.