ArticleEpilepsy currents2010
Primary and secondary mechanisms of epileptogenesis in the temporal lobe: there is a before and an after.
Article in Epilepsy currents, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- The Plasminogen Activation System in the Central Nervous System: Implications for Epilepsy and Neuropsychiatric Disorders.International journal of molecular sciences · 2025Review
- Upregulation of CCK3R leading to the suppression of chronic seizures.Translational psychiatry · 2025Article
- Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions.Pharmacological reviews · 2025Review
- Converting "nonlesional" imaging occult epilepsy into a focal lesional entity using advanced imaging techniques: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Expansion of epileptogenic networks via neuroplasticity in neural mass models.PLoS computational biology · 2024Article
- Extra-temporal pediatric low-grade gliomas and epilepsy.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2024Review
- Low-frequency Stimulation at the Subiculum Prevents Extensive Secondary Epileptogenesis in Temporal Lobe Epilepsy.Neuroscience bulletin · 2024Article
- The rearrangement of actin cytoskeleton in mossy fiber synapses in a model of experimental febrile seizures.Frontiers in neurology · 2023Article
- Unilateral optogenetic kindling of hippocampus leads to more severe impairments of the inhibitory signaling in the contralateral hippocampus.Frontiers in molecular neuroscience · 2023Article
- The Temporal and Spatial Changes of Th17, Tregs, and Related Cytokines in Epilepsy Lesions.Applied bionics and biomechanics · 2022Article
- Secondary Epileptogenesis: Common to See, but Possible to Treat?Frontiers in neurology · 2021Review
- Characterization of kindled VGAT-Cre mice as a new animal model of temporal lobe epilepsy.Epilepsia · 2020Article
- HAP1 Modulates Epileptic Seizures by Regulating GABANeurochemical research · 2020Article
- Characterization and treatment of spontaneous recurrent seizures following nerve agent-induced status epilepticus in mice.Epilepsy research · 2020Article
- Factors associated with seizure and cognitive outcomes after epilepsy surgery for low-grade epilepsy-associated neuroepithelial tumors in children.Clinical and experimental pediatrics · 2020Article
- An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy.Cell reports · 2019Article
- Calpain activation and neuronal death during early epileptogenesis.Neurobiology of disease · 2019Article
- Theiler's murine encephalomyelitis virus infection of SJL/J and C57BL/6J mice: Models for multiple sclerosis and epilepsy.Journal of neuroimmunology · 2017Review
- Low-frequency stimulation of the primary focus retards positive transfer of secondary focus.Scientific reports · 2017Article
- Altered microRNA profiles in plasma exosomes from mesial temporal lobe epilepsy with hippocampal sclerosis.Oncotarget · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extensive data involving several animal models of temporal lobe epilepsy highlight synaptic alterations that likely act synergistically during acquired epileptogenesis. Most of this research has utilized experimental models in which intense electrical activity in adult animals, primarily involving status epilepticus, causes variable neuronal death in the hippocampus and other temporal lobe structures. Neuronal death, including principal cells and specific interneurons, likely has several roles in epileptogenesis after brain injury. Both reduction of GABA-mediated inhibition from selective interneuron loss and the progressive formation of new recurrent excitatory circuits after death of principal neurons enhance excitability and promote seizures during the development of epilepsy. These epileptogenic circuits hypothetically continue to undergo secondary epileptogenesis, which involves further modifications that contribute to a progressive, albeit variable, increase in the frequency and severity of spontaneous recurrent seizures.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.