Evidence map›Paper›PMID 20944134›Full record

ArticleAnticancer research2010

Decreased Srcasm expression in esophageal squamous cell carcinoma in a Chinese population.

Yu Qi, Xin Li, Liang Zhao, John T Seykora

Abstract read
PubMed Full text at PMC
In one paragraph

Article in Anticancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yu QiDepartment of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, PRC. ekansqy@gmail.com
Xin Li
Liang Zhao
John T Seykora
First Affiliated Hospital of Zhengzhou University · CN

Funding

Understanding molecular mechanisms underlying the formation of the blue nevus andP30AR057217 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI STANLEY, JOHN R · 2009 to 2013
$3.2M
The role of srcasm in keratinocyte biologyR01AR051380 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI SEYKORA, JOHN T. · 2005 to 2009
$1.6M
NIAMS NIH HHS P30 AR057217NIAMS NIH HHS R01 AR051380
6 · The paper itself

Abstract

backgroundSrc-family tyrosine kinases (SFKs) play critical roles in regulating cellular differentiation and proliferation. Src-activating and signaling molecule (Srcasm) is a novel molecule that down-regulates SFK activity and promotes cell differentiation. The aim of this study was to determine whether Srcasm expression was altered in esophageal squamous epithelial carcinoma compared with normal epithelium in a Chinese population. MATERIALS AND

methodsWe examined Srcasm immunohistochemical staining in 30 cases in both normal esophageal epithelium and esophageal squamous cell carcinoma (SCC) from the same patient in formalin-fixed paraffin embedded tissue blocks.

resultsSrcasm protein expression levels are decreased in esophageal SCC compared to the esophageal normal epithelium.

conclusionThis pattern of Srcasm expression suggests that it may act as a negative regulator in esophageal SCC cell signaling.

Indexed as

Adaptor Proteins, Signal TransducingAsian PeopleBlotting, WesternCarcinoma, Squamous CellEsophageal NeoplasmsHumansImmunohistochemistrySignal TransductionAdaptor Proteins, Signal TransducingTOM1L1 protein, human

Identifiers

PMID20944134
PMCPMC3107990
OpenAlexW2116269853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.