ArticleAnticancer research2010
NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species.
Article in Anticancer research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
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- Inactivation Mechanism of Escherichia coli Induced by Slightly Acidic Electrolyzed Water.Scientific reports · 2017Article
- Type VI secretion system contributes to Enterohemorrhagic Escherichia coli virulence by secreting catalase against host reactive oxygen species (ROS).PLoS pathogens · 2017Article
- Research of Brucea javanica against cancer.Chinese journal of integrative medicine · 2017Review
- New acyclic bis phenylpropanoid and neolignans, from Myristica fragrans Houtt., exhibiting PARP-1 and NF-κB inhibitory effects.Food chemistry · 2016Article
- Suppression of human hepatocellular cancer cell proliferation by Brucea javanica oil-loaded liposomes via induction of apoptosis.Archives of medical science : AMS · 2015Article
- Ambiguine I Isonitrile fromInternational journal of cancer research · 2015Article
- Crebanine, an aporphine alkaloid, sensitizes TNF-α-induced apoptosis and suppressed invasion of human lung adenocarcinoma cells A549 by blocking NF-κB-regulated gene products.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Apoptosis induction by 13-acetoxyrolandrolide through the mitochondrial intrinsic pathway.Phytotherapy research : PTR · 2014Article
- Apoptosis-inducing effect of three medicinal plants on oral cancer cells KB and ORL-48.TheScientificWorldJournal · 2014Article
- Dichamanetin inhibits cancer cell growth by affecting ROS-related signaling components through mitochondrial-mediated apoptosis.Anticancer research · 2013Article
- Apoptotic Effect of Wortmannolone on Cancer Cells through Potent ROS Induction.International journal of cancer research · 2013Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimBrucea javanica was studied to identify nuclear factor kappaB (NF-κB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND
methodsEight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-κB assay. Active compounds were then tested using ROS and mitochondria transmembrane potential (MTP) assays. NF-κB and nuclear factor activated T-cell (NFAT) translocation were also assessed using their respective whole cell assays.
resultsBruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-κB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells with greater potency and also showed an ability to up-regulate NFAT transcriptional pathways through the amplification of intracellular ROS, in the presence of H2O2, to a greater degree than bruceantin and bruceine.
conclusionChrysoeriol selectively kills leukemic cells and potentiates the amplification of ROS levels. Therefore, chrysoeriol could serve as a potential chemotherapeutic modifier for leukemia chemotherapy since leukemia cells have a higher susceptibility to elevated ROS levels.
Indexed as
Identifiers
20944100PMC3013507W2144578753What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.