ArticleBiology of reproduction2011
Sertoli cell behaviors in developing testis cords and postnatal seminiferous tubules of the mouse.
Article in Biology of reproduction, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- Trimester Specific Anatomical and Histological Characterization of Testicular Descent and Development in Sheep Foetuses.Veterinary medicine and science · 2026Article
- Brain-Specific Gata4 Downregulation in Greywick Female Mice Models the Metabolic Subtype of Polycystic Ovary Syndrome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Comparative RNA-Seq analysis of differentially expressed genes in the sertoli cells of yak and cattle-yak.BMC veterinary research · 2025Article
- Targeted Disruption of Lats1 and Lats2 in Mice Impairs Testis Development and Alters Somatic Cell Fate.International journal of molecular sciences · 2022Article
- Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene Expression.Frontiers in endocrinology · 2022Review
- REPRODUCTIVE TOXICOLOGY: Environmental exposures, fetal testis development and function: phthalates and beyond.Reproduction (Cambridge, England) · 2021Review
- Sertoli cell-derived exosome-mediated transfer of miR-145-5p inhibits Leydig cell steroidogenesis by targeting steroidogenic factor 1.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Challenging human somatic testicular cell reassembly by protein kinase inhibition -setting up a functional in vitro test system.Scientific reports · 2020Article
- Mapping molecular pathways for embryonic Sertoli cells derivation based on differentiation model of mouse embryonic stem cells.Stem cell research & therapy · 2020Article
- Inducing Non-genetically Modified Induced Embryonic Sertoli Cells Derived From Embryonic Stem Cells With Recombinant Protein Factors.Frontiers in cell and developmental biology · 2020Article
- Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells.Stem cell research & therapy · 2019Article
- Expression dynamics of self-renewal factors for spermatogonial stem cells in the mouse testis.The Journal of reproduction and development · 2018Article
- Article
- Fetal testis organ culture reproduces the dynamics of epigenetic reprogramming in rat gonocytes.Epigenetics & chromatin · 2017Article
- UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.Development (Cambridge, England) · 2015Article
- Computer simulations of the mouse spermatogenic cycle.Biology open · 2014Article
- Generation of a dual-color reporter mouse line to monitor spermatogenesis in vivo.Frontiers in cell and developmental biology · 2014Article
- Building the mammalian testis: origins, differentiation, and assembly of the component cell populations.Genes & development · 2013Review
- Direct reprogramming of fibroblasts into embryonic Sertoli-like cells by defined factors.Cell stem cell · 2012Article
- The Drosophila cyst stem cell lineage: Partners behind the scenes?Spermatogenesis · 2012Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
Abstract
Sertoli cells are the primary structural component of the fetal testis cords and postnatal seminiferous tubules. Live imaging technologies facilitate the visualization of cell morphologies and behaviors through developmental processes. A transgenic mouse line was generated using a fragment of the rat Gata4 gene to direct the expression of a dual-color fluorescent protein reporter in fetal and adult Sertoli cells. The reporter encoded a red fluorescent protein, monomeric Cherry (mCherry), fused to histone 2B and enhanced green fluorescent protein (EGFP) fused to a glycosylphosphatidylinositol sequence, with a self-cleaving 2A polypeptide separating the two fusion proteins. After translation, the red and green fluorescent proteins translocated to the nucleus and plasma membrane, respectively, of Sertoli cells. Transgene expression in testes was first detected by fluorescent microscopy around Embryonic Day 12.0. Sertoli cell division and migration were visualized during testis cord formation in organ culture. Initially, the Sertoli cells had mesenchyme-like morphologies and behaviors, but later, the cells migrated to the periphery of the testis cords to become epithelialized. In postnatal seminiferous tubules, Sertoli nuclei were evenly spaced when viewed from the external surface of tubules, and Sertoli cytoplasm and membranes were associated with germ cells basally in a rosette pattern. This mouse line was bred to previously described transgenic mouse lines expressing EGFP in Sertoli cytoplasm or a nuclear cyan fluorescent protein (Cerulean) and mCherry in plasma membranes of germ cells. This revealed the physical relationship between Sertoli and germ cells in developing testis cords and provided a novel perspective on Sertoli cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.