ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Rapid T cell receptor delineation reveals clonal expansion limitation of the magnitude of the HIV-1-specific CD8+ T cell response.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
- Novel, in-natural-infection subdominant HIV-1 CD8+ T-cell epitopes revealed in human recipients of conserved-region T-cell vaccines.PloS one · 2017Trial
- Immunization of BLT Humanized Mice Redirects T Cell Responses to Gag and Reduces Acute HIV-1 Viremia.Journal of virology · 2019Article
- CD8Viral immunology · 2018Article
- HIV-1 Epitope Variability Is Associated with T Cell Receptor Repertoire Instability and Breadth.Journal of virology · 2017Article
- HIV-1 epitopes presented by MHC class I types associated with superior immune containment of viremia have highly constrained fitness landscapes.PLoS pathogens · 2017Article
- Genetic Modulation Therapy Through Stem Cell Transplantation for Human Immunodeficiency Virus 1 Infection.Cureus · 2017Review
- Supranormal thymic output up to 2 decades after HIV-1 infection.AIDS (London, England) · 2016Article
- High-Throughput Sequencing-Based Immune Repertoire Study during Infectious Disease.Frontiers in immunology · 2016Review
- Clonal CD8+ T Cell Persistence and Variable Gene Usage Bias in a Human Transplanted Hand.PloS one · 2015Article
- Host genetics and viral load in primary HIV-1 infection: clear evidence for gene by sex interactions.Human genetics · 2014Article
- Engineering the human thymic microenvironment to support thymopoiesis in vivo.Stem cells (Dayton, Ohio) · 2014Article
- Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection.Cellular & molecular immunology · 2014Article
- Stem-cell-based gene therapy for HIV infection.Viruses · 2013Review
- Long-term human immune system reconstitution in non-obese diabetic (NOD)-Rag (-)-γ chain (-) (NRG) mice is similar but not identical to the original stem cell donor.Clinical and experimental immunology · 2013Article
- Introduction of exogenous T-cell receptors into human hematopoietic progenitors results in exclusion of endogenous T-cell receptor expression.Molecular therapy : the journal of the American Society of Gene Therapy · 2013Article
- Early HLA-B*57-restricted CD8+ T lymphocyte responses predict HIV-1 disease progression.Journal of virology · 2012Article
- Stem cell-based anti-HIV gene therapy.Virology · 2011Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
TCRs mediate CTL specificity, but TCRs recognizing the same epitope often differ between persons due to their stochastic derivation. The role of this variability in the pathogenesis of virus infections and malignancies has been technically difficult to study. We apply an adaptation of TCR spectratyping to study HIV-specific CTLs, defining the clonal breadth and sequences of epitope-specific TCRs from PBMCs without cellular sorting or molecular cloning. Examining 48 CTL responses in 12 persons reveals a mean of 4.5 ± 2.7 clones per response, of both public and private clonotypes. The number of identified epitope-specific TCRs correlates with CTL frequency across epitopes, suggesting that clonal breadth limits the magnitude of the CTL response against HIV-1 in vivo. HLA A- and B-restricted CTLs are similar in their TCR breadth in this small cohort, preliminarily suggesting that qualitative differences may account for their disparate impacts on pathogenesis. Overall, these findings demonstrate that the magnitude of the CTL response in chronic HIV-1 infection is constrained by TCR clonal breadth, suggesting maximal expansion of CTLs in response to chronic antigenic stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.