ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Prototypic seizure activity driven by mature hippocampal fast-spiking interneurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.
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Who cites it
50 citing papers in PubMed, 1 synthesis or guideline pooled it.
- GABAFrontiers in neural circuits · 2022Pooled it
- WNK-SPAK/OSR1 signaling pathway facilitates ictal activity via reduced neuronal chloride extrusion rate.bioRxiv : the preprint server for biology · 2026Article
- GABACellular and molecular neurobiology · 2026Review
- Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone.BMC medicine · 2026Article
- Dynamics and conditions for inhibitory synaptic current to induce bursting and spreading depolarization in pyramidal neurons.Scientific reports · 2025Article
- Article
- Article
- Balloon cells in malformations of cortical development: friends or foes?Acta epileptologica · 2024Review
- A genetically targeted ion sensor reveals distinct seizure-related chloride and pH dynamics in GABAergic interneuron populations.iScience · 2023Article
- Why won't it stop? The dynamics of benzodiazepine resistance in status epilepticus.Nature reviews. Neurology · 2022Review
- Disrupting Epileptiform Activity by Preventing Parvalbumin Interneuron Depolarization Block.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Perampanel reduces paroxysmal depolarizing shift and inhibitory synaptic input in excitatory neurons to inhibit epileptic network oscillations.British journal of pharmacology · 2020Article
- Learning to define an electrical biomarker of the epileptogenic zone.Human brain mapping · 2020Article
- Excitatory GABAergic signalling is associated with benzodiazepine resistance in status epilepticus.Brain : a journal of neurology · 2019Article
- Divergent paths to seizure-like events.Physiological reports · 2019Article
- KCC2 overexpression prevents the paradoxical seizure-promoting action of somatic inhibition.Nature communications · 2019Article
- Evolving Mechanistic Concepts of Epileptiform Synchronization and their Relevance in Curing Focal Epileptic Disorders.Current neuropharmacology · 2019Review
- Interneuronal Network Activity at the Onset of Seizure-Like Events in Entorhinal Cortex Slices.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Hippocampal GABAergic Inhibitory Interneurons.Physiological reviews · 2017Review
- Involvement of fast-spiking cells in ictal sequences during spontaneous seizures in rats with chronic temporal lobe epilepsy.Brain : a journal of neurology · 2017Article
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8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A variety of epileptic seizure models have shown that activation of glutamatergic pyramidal cells is usually required for rhythm generation and/or synchronization in hippocampal seizure-like oscillations in vitro. However, it still remains unclear whether GABAergic interneurons may be able to drive the seizure-like oscillations without glutamatergic transmission. Here, we found that electrical stimulation in rat hippocampal CA1 slices induced a putative prototype of seizure-like oscillations ("prototypic afterdischarge," 1.8-3.8 Hz) in mature pyramidal cells and interneurons in the presence of ionotropic glutamate receptor antagonists. The prototypic afterdischarge was abolished by GABA(A) receptor antagonists or gap junction blockers, but not by a metabotropic glutamate receptor antagonist or a GABA(B) receptor antagonist. Gramicidin-perforated patch-clamp and voltage-clamp recordings revealed that pyramidal cells were depolarized and frequently excited directly through excitatory GABAergic transmissions in each cycle of the prototypic afterdischarge. Interneurons that were actively spiking during the prototypic afterdischarge were mostly fast-spiking (FS) interneurons located in the strata oriens and pyramidale. Morphologically, these interneurons that might be "potential seizure drivers" included basket, chandelier, and bistratified cells. Furthermore, they received direct excitatory GABAergic input during the prototypic afterdischarge. The O-LM cells and most of the interneurons in the strata radiatum and lacunosum moleculare were not essential for the generation of prototypic afterdischarge. The GABA-mediated prototypic afterdischarge was observed later than the third postnatal week in the rat hippocampus. Our results suggest that an FS interneuron network alone can drive the prototypic form of electrically induced seizure-like oscillations through their excitatory GABAergic transmissions and presumably through gap junction-mediated communications.
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