ArticleThe American journal of clinical nutrition2010
Adherence to a Mediterranean diet and plasma concentrations of lipid peroxidation in premenopausal women.
Article in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 60 citations in OpenAlex.
- Pooled it
- The Association between the Mediterranean Dietary Pattern and Cognitive Health: A Systematic Review.Nutrients · 2017Pooled it
- Proposal for a Breakfast Quality Index (BQI) for children and adolescents.Public health nutrition · 2013Trial
- The effect of Mediterranean Diet adherence on the relationship between cognitive performance and cancer survivorship.Journal of cancer survivorship : research and practice · 2026Article
- Historical rise of cancer and dietary linoleic acid: Mechanisms and therapeutic strategies.World journal of clinical oncology · 2025Review
- Association between healthy dietary patterns and markers of oxidative stress in the Sister Study.European journal of nutrition · 2024Article
- Mediterranean Diet Adherence and Depressive Symptoms among a Nationally Representative Sample of Pregnant Women in the United States.The Journal of nutrition · 2023Article
- Article
- Adherence to a Mediterranean Diet Is Associated with Lower Depressive Symptoms among U.S. Adults.Nutrients · 2022Article
- Article
- Article
- Dietary Intakes of Vitamin B-2 (Riboflavin), Vitamin B-6, and Vitamin B-12 and Ovarian Cycle Function among Premenopausal Women.Journal of the Academy of Nutrition and Dietetics · 2020Article
- Mediterranean Diet Nutrients to Turn the Tide against Insulin Resistance and Related Diseases.Nutrients · 2020Review
- Oleuropein derivatives from olive fruit extracts reduce α-synuclein fibrillation and oligomer toxicity.The Journal of biological chemistry · 2019Article
- Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with All-Cause and Cause-Specific Mortality in Adults.The Journal of nutrition · 2017Article
- Serum caffeine and paraxanthine concentrations and menstrual cycle function: correlations with beverage intakes and associations with race, reproductive hormones, and anovulation in the BioCycle Study.The American journal of clinical nutrition · 2016Article
- Paleolithic and Mediterranean Diet Pattern Scores Are Inversely Associated with Biomarkers of Inflammation and Oxidative Balance in Adults.The Journal of nutrition · 2016Article
- The relationship between sugar-sweetened beverages and liver enzymes among healthy premenopausal women: a prospective cohort study.European journal of nutrition · 2016Article
- The Deep Correlation between Energy Metabolism and Reproduction: A View on the Effects of Nutrition for Women Fertility.Nutrients · 2016Review
- Alcohol intake, reproductive hormones, and menstrual cycle function: a prospective cohort study.The American journal of clinical nutrition · 2015Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundA Mediterranean diet has been associated with a reduced risk of cardiovascular disease and mortality. A possible mechanism is through a decrease in lipid peroxidation (LPO); however, evidence linking the Mediterranean diet with lower LPO in premenopausal women is sparse.
objectiveWe investigated whether adherence to a Mediterranean diet was associated with lower LPO concentrations in premenopausal women.
designTwo hundred fifty-nine healthy women aged 18-44 y were followed for ≤ 2 menstrual cycles. Plasma concentrations of F(2)-isoprostane (8-iso-PGF2α), 9-hydroxyoctadecadieneoic acid (9-HODE), and thiobarbituric acid reactive substances (TBARS) were measured ≤ 8 times per cycle at visits scheduled by using fertility monitors. Diet was assessed ≤ 4 times per cycle by using 24-h dietary recalls. The alternate Mediterranean Diet Score (aMED) (range: 0-9) was calculated on the basis of intake of vegetables, legumes, fruit, nuts, whole grains, red and processed meat, fish, and alcohol and the ratio of monounsaturated to saturated fat.
resultsA 1-unit increase in aMED was associated with a 4.50% decrease in 8-iso-PGF2α concentrations (95% CI: -6.32%, -2.65%) and a 14.01% decrease in 9-HODE concentrations (95% CI: -17.88%, -9.96%) after adjustment for energy intake, age, race, body mass index, plasma ascorbic acid, and serum cholesterol. No significant association was observed between aMED and TBARS. A 1-unit increase in aMED was associated with a 1.39% increase (95% CI: 0.07%, 2.72%) in plasma ascorbic acid concentrations.
conclusionsAdherence to a Mediterranean diet is associated with lower LPO and higher ascorbic acid concentrations. These results confirm that decreased LPO is a plausible mechanism linking a Mediterranean diet to reduced cardiovascular disease risk.
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