ArticleAmerican journal of physiology. Renal physiology2011
Oxidative stress alters renal D1 and AT1 receptor functions and increases blood pressure in old rats.
Article in American journal of physiology. Renal physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Comprehensive insights in GRK4 and hypertension: From mechanisms to potential therapeutics.Pharmacology & therapeutics · 2022Review
- Pressure-Natriuresis Response Is Diminished in Old Age.Frontiers in cardiovascular medicine · 2022Article
- Role of protein phosphatase 2A in kidney disease (Review).Experimental and therapeutic medicine · 2021Review
- Protective potential of curcumin in L-NAME-induced hypertensive rat model: AT1R, mitochondrial DNA synergy.International journal of physiology, pathophysiology and pharmacology · 2020Article
- Genetic polymorphisms associated with reactive oxygen species and blood pressure regulation.The pharmacogenomics journal · 2019Review
- Superoxide via Sp3 mechanism increases renal renin activity, renal AT1 receptor function, and blood pressure in rats.American journal of physiology. Renal physiology · 2018Article
- Exposure to Maternal Diabetes Mellitus Causes Renal Dopamine DHypertension (Dallas, Tex. : 1979) · 2018Article
- Mechanisms of altered renal sodium handling in age-related hypertension.American journal of physiology. Renal physiology · 2018Review
- DR1 activation reduces the proliferation of vascular smooth muscle cells by JNK/c-Jun dependent increasing of Prx3.Molecular and cellular biochemistry · 2018Article
- Superoxide increases angiotensin II AT1 receptor function in human kidney-2 cells.FEBS open bio · 2016Article
- Curcumin Exerts its Anti-hypertensive Effect by Down-regulating the AT1 Receptor in Vascular Smooth Muscle Cells.Scientific reports · 2016Article
- Dopamine D2 receptors' effects on renal inflammation are mediated by regulation of PP2A function.American journal of physiology. Renal physiology · 2016Article
- Grape Powder Improves Age-Related Decline in Mitochondrial and Kidney Functions in Fischer 344 Rats.Oxidative medicine and cellular longevity · 2016Article
- Chronic NF-κB blockade improves renal angiotensin II type 1 receptor functions and reduces blood pressure in Zucker diabetic rats.Cardiovascular diabetology · 2015Article
- Antihypertensive mechanisms of intra-renal dopamine.Current opinion in nephrology and hypertension · 2015Review
- Oxidative stress causes imbalance of renal renin angiotensin system (RAS) components and hypertension in obese Zucker rats.Journal of the American Heart Association · 2015Article
- Prenatal lipopolysaccharide exposure results in dysfunction of the renal dopamine D1 receptor in offspring.Free radical biology & medicine · 2014Article
- Exosomal transfer from human renal proximal tubule cells to distal tubule and collecting duct cells.Clinical biochemistry · 2014Article
- A high-salt diet further impairs age-associated declines in cognitive, behavioral, and cardiovascular functions in male Fischer brown Norway rats.The Journal of nutrition · 2013Article
- A linear relationship between the ex-vivo sodium mediated expression of two sodium regulatory pathways as a surrogate marker of salt sensitivity of blood pressure in exfoliated human renal proximal tubule cells: the virtual renal biopsy.Clinica chimica acta; international journal of clinical chemistry · 2013Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Aging is associated with an increase in oxidative stress and blood pressure (BP). Renal dopamine D1 (D1R) and angiotensin II AT1 (AT1R) receptors maintain sodium homeostasis and BP. We hypothesized that age-associated increase in oxidative stress causes altered D1R and AT1R functions and high BP in aging. To test this, adult (3 mo) and old (21 mo) Fischer 344 × Brown Norway F1 rats were supplemented without/with antioxidant tempol followed by determining oxidative stress markers (urinary antioxidant capacity, proximal tubular NADPH-gp91phox, and plasma 8-isoprostane), D1R and AT1R functions, and BP. The D1R and AT1R functions were determined by measuring diuretic and natriuretic responses to D1R agonist (SKF-38393; 1 μg·kg(-1)·min(-1) iv) and AT1R antagonist (candesartan; 10 μg/kg iv), respectively. We found that the total urinary antioxidant capacity was lower in old rats, which increased with tempol treatment. In addition, tempol decreased the elevated NADPH-gp91phox and 8-isoprostane levels in old rats. Systolic, diastolic, and mean arterial BPs were higher in old rats and were reduced by tempol. Although SKF-38393 produced diuresis in both adult and old rats, urinary sodium excretion (UNaV) increased only in adult rats. While candesartan increased diuresis and UNaV in adult and old rats, the magnitude of response was greater in old rats. Tempol treatment in old rats reduced candesartan-induced increase in diuresis and UNaV. Our results demonstrate that diminished renal D1R and exaggerated AT1R functions are associated with high BP in old rats. Furthermore, oxidative stress may cause altered renal D1R and AT1R functions and high BP in old rats.
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