ReviewCold Spring Harbor perspectives in biology2010
Nuclear organization and dosage compensation.
Review in Cold Spring Harbor perspectives in biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- The Molecular and Nuclear Dynamics of X-Chromosome Inactivation.Cold Spring Harbor perspectives in biology · 2022Review
- Dosage compensation inProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Involvement of X-chromosome Reactivation in Augmenting Cancer Testis Antigens Expression: A Hypothesis.Current medical science · 2018Article
- Unique transposon landscapes are pervasive across Drosophila melanogaster genomes.Nucleic acids research · 2015Article
- Random monoallelic expression of autosomal genes: stochastic transcription and allele-level regulation.Nature reviews. Genetics · 2015Review
- The inactive X chromosome is epigenetically unstable and transcriptionally labile in breast cancer.Genome research · 2015Article
- The lncRNA Firre anchors the inactive X chromosome to the nucleolus by binding CTCF and maintains H3K27me3 methylation.Genome biology · 2015Article
- Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions.Nucleic acids research · 2015Review
- Linking dosage compensation and X chromosome nuclear organization in C. elegans.Nucleus (Austin, Tex.) · 2015Article
- Genomic imprinting effects on complex traits in domesticated animal species.Frontiers in genetics · 2015Review
- Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans.Genes & development · 2014Article
- Random monoallelic expression: regulating gene expression one allele at a time.Trends in genetics : TIG · 2014Review
- Article
- Long non-coding RNAs and human X-chromosome regulation: a coat for the active X chromosome.RNA biology · 2013Article
- Human inactive X chromosome is compacted through a PRC2-independent SMCHD1-HBiX1 pathway.Nature structural & molecular biology · 2013Article
- Dosage compensation of the sex chromosomes.Annual review of genetics · 2012Review
- Sex chromosome evolution in moths and butterflies.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2012Article
- X-inactivation and X-reactivation: epigenetic hallmarks of mammalian reproduction and pluripotent stem cells.Human genetics · 2011Article
- The demoiselle of X-inactivation: 50 years old and as trendy and mesmerising as ever.PLoS genetics · 2011Review
- MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells.Genes & development · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dosage compensation is a strategy to deal with the imbalance of sex chromosomal gene products relative to autosomes and also between the sexes. The mechanisms that ensure dosage compensation for X-chromosome activity have been extensively studied in mammals, worms, and flies. Although each entails very different mechanisms to equalize the dose of X-linked genes between the sexes, they all involve the co-ordinate regulation of hundreds of genes specifically on the sex chromosomes and not the autosomes. In addition to chromatin modifications and changes in higher order chromatin structure, nuclear organization is emerging as an important component of these chromosome-wide processes and in the specific targeting of dosage compensation complexes to the sex chromosomes. Preferential localization within the nucleus and 3D organization are thought to contribute to the differential treatment of two identical homologs within the same nucleus, as well as to the chromosome-wide spread and stable maintenance of heterochromatin.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.