ArticleEuropean heart journal2011
Benefit of atrial septal defect closure in adults: impact of age.
Article in European heart journal, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 2 of them syntheses that pooled it.
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Who cites it
58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Transcatheter closure of atrial septal defect in the elderly: a systematic review and meta-analysis.Heart (British Cardiac Society) · 2023Pooled it
- Prevalence and outcomes of pulmonary hypertension after percutaneous closure of atrial septal defect: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2020Pooled it
- Long-Term Outcomes of Atrial Septal Defect Closure in Adults Older than 50 Years.Pediatric cardiology · 2026Article
- Treat-and-repair Strategy for Atrial Septal Defect with Eisenmenger Syndrome due to Pulmonary Arterial Hypertension.Internal medicine (Tokyo, Japan) · 2026Article
- [Consensus recommendation of the Austrian Society of Cardiology: anatomy, pathophysiology, diagnosis and treatment of arrhythmias in adult patients with congenital heart disease].Wiener klinische Wochenschrift · 2026Review
- Staged Therapeutic Approach to Concomitant Severe Aortic Stenosis and Atrial Septal Defect: Addressing Dual Mechanisms of Heart Failure-Case Report and Literature Review.Life (Basel, Switzerland) · 2026Article
- Long-Term Postoperative Outcomes of Sinus Venosus Defect.Journal of clinical medicine · 2026Article
- Incidence and Predictive Factors for Surgical Interventions Following Simple Congenital Heart Disease Interventional Transcatheter/Interventional Procedure.Journal of cardiovascular development and disease · 2026Article
- Unrepaired Congenital Shunt Lesions in Adults: Principles for Clinical Management.Methodist DeBakey cardiovascular journal · 2026Review
- Left atrial functional remodeling following percutaneous closure of atrial septal defect secundum in adult patients.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025Article
- Atrial Septal Defect and Heart Rhythm Disorders: Physiopathological Linkage and Clinical Perspectives.Biomedicines · 2025Review
- Dual-Phase Increase in Atrial Arrhythmia Prevalence Following Percutaneous Atrial Septal Defect Closure.Journal of the Society for Cardiovascular Angiography & Interventions · 2025Article
- Comparing the impact of transcatheter ASD closure on echocardiographic indices in adults below and above 50 years.Echo research and practice · 2025Article
- Cardiovascular outcomes in adult patients with atrial septal defect: a nationwide population-based study.Frontiers in cardiovascular medicine · 2025Article
- Biodegradable polymeric occluder with controllable locking structure for closure of atrial septal defect via interventional treatment.Regenerative biomaterials · 2025Article
- The valuable role of cardio-pulmonary exercise testing in the diagnosis of atrial septal defect in a competitive triathlete: a case report.European heart journal. Case reports · 2024Article
- Initial Experience With an Amplatzer Cribriform Occluder in Patients With Atrial Septal Defects in Pakistan.Cureus · 2024Article
- Development and Validation of a Nomogram of Persistent Pulmonary Hypertension in Adult Pretricuspid Shunts After Correction.Journal of the American Heart Association · 2024Article
- Arrhythmic Risk and Treatment after Transcatheter Atrial Septal Defect Closure.Diagnostics (Basel, Switzerland) · 2023Review
- Twin pregnancy with sudden heart failure and pulmonary hypertension after atrial septal defect repair: A case report.World journal of clinical cases · 2023Article
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Authors and funding
11 authors at 1 institution in 2 countries.
Funding
Abstract
aimsTo evaluate the effect of age on the clinical benefit of atrial septal defect (ASD) closure in adults. METHODS AND
resultsFunctional status, the presence of arrhythmias, right ventricular (RV) remodelling, and pulmonary artery pressure (PAP) were studied in 236 consecutive patients undergoing transcatheter ASD closure [164 females, mean age of 49 ± 18 years, 78 younger than 40 years (Group A), 84 between 40 and 60 years (Group B) and 74 older than 60 years (Group C)]. Defect size [median 22 mm (inter-quartile range, 19, 26 mm)] and shunt ratio [Qp:Qs 2.2 (1.7, 2.9)] did not differ among age groups. Older patients had, however, more advanced symptoms and both, PAP (r = 0.65, P < 0.0001) and RV size (r = 0.28, P < 0.0001), were significantly related to age. Post-interventionally, RV size decreased from 41 ± 7, 43 ± 7, and 45 ± 6 mm to 32 ± 5, 34 ± 5, and 37 ± 5 mm for Groups A, B, and C, respectively (P < 0.0001), and PAP decreased from 31 ± 7, 37 ± 10, and 53 ± 17 mmHg to 26 ± 5, 30 ± 6, and 43 ± 14 mmHg (P < 0.0001), respectively. Absolute changes in RV size (P = 0.80) and PAP (P = 0.24) did not significantly differ among groups. Symptoms were present in 13, 49, and 83% of the patients before and in 3, 11, and 34% after intervention in Groups A, B, and C. Functional status was related to PAP.
conclusionsAt any age, ASD closure is followed by symptomatic improvement and regression of PAP and RV size. However, the best outcome is achieved in patients with less functional impairment and less elevated PAP. Considering the continuous increase in symptoms, RV remodelling, and PAP with age, ASD closure must be recommended irrespective of symptoms early after diagnosis even in adults of advanced age.
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