ArticleClinical immunology (Orlando, Fla.)2011
Identification of Hnrph3 as an autoantigen for acute anterior uveitis.
Article in Clinical immunology (Orlando, Fla.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 20 citations in OpenAlex.
- PhIP-Seq: methods, applications and challenges.Frontiers in bioinformatics · 2024Review
- Phage ImmunoPrecipitation Sequencing (PhIP-Seq): The Promise of High Throughput Serology.Pathogens (Basel, Switzerland) · 2022Review
- A Master Autoantigen-ome Links Alternative Splicing, Female Predilection, and COVID-19 to Autoimmune Diseases.bioRxiv : the preprint server for biology · 2021Article
- Anti-secretogranin III therapy of oxygen-induced retinopathy with optimal safety.Angiogenesis · 2019Article
- Secretogranin III as a disease-associated ligand for antiangiogenic therapy of diabetic retinopathy.The Journal of experimental medicine · 2017Article
- Lyar Is a New Ligand for Retinal Pigment Epithelial Phagocytosis.Journal of cellular biochemistry · 2015Article
- ABCF1 extrinsically regulates retinal pigment epithelial cell phagocytosis.Molecular biology of the cell · 2015Article
- Interaction analysis through proteomic phage display.BioMed research international · 2014Review
- A proteomics view of the molecular mechanisms and biomarkers of glaucomatous neurodegeneration.Progress in retinal and eye research · 2013Review
- Immunoproteomic analysis of potential serum biomarker candidates in human glaucoma.Investigative ophthalmology & visual science · 2012Article
- Phage display--a powerful technique for immunotherapy: 1. Introduction and potential of therapeutic applications.Human vaccines & immunotherapeutics · 2012Review
- ORF phage display to identify cellular proteins with different functions.Methods (San Diego, Calif.) · 2012Article
- Galectin-3 is a new MerTK-specific eat-me signal.Journal of cellular physiology · 2012Article
- Cutting-edge issues in autoimmune uveitis.Clinical reviews in allergy & immunology · 2011Review
- Autoantigen discovery with a synthetic human peptidome.Nature biotechnology · 2011Article
- Identification of calpain substrates by ORF phage display.Molecules (Basel, Switzerland) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Acute anterior uveitis (AAU) is the most common form of autoimmune uveitis in the eye with few known autoantigens. Identification of autoantigens will improve our understanding of the molecular mechanisms and capability for disease diagnosis. Phage display is a powerful technology for autoantigen identification. However, because of uncontrollable reading frames, phage display with conventional cDNA libraries identifies high percentage of non-open reading frames (non-ORFs) with minimal implications for autoantigen identification. We recently developed ORF phage display technology with minimal reading frame problem. Herein we used ORF phage display to identify 18 patient-specific clones, including 16 ORFs encoding endogenous proteins as candidate autoantigens for AAU. One of the identified antigens was heterogeneous nuclear ribonucleoprotein H3 (Hnrph3) that was further characterized for AAU relevance and independently verified by Western blot. These results demonstrate that ORF phage display is a valuable approach for identification of unknown autoantigens.
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Registered trials
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