ArticleBMC microbiology2010
Strain-specific differences in pili formation and the interaction of Corynebacterium diphtheriae with host cells.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.PLoS genetics · 2023Article
- Interactions between the Re-Emerging PathogenInternational journal of molecular sciences · 2022Review
- Phylogenomic Characterization of a NovelmSystems · 2021Article
- Newly Isolated Animal PathogenInternational journal of molecular sciences · 2021Article
- Genomic epidemiology of nontoxigenicMicrobial genomics · 2020Article
- Phylogenomic characterisation of a novel corynebacterial species pathogenic to animals.Antonie van Leeuwenhoek · 2020Article
- Genome-wide comparison of Corynebacterium diphtheriae isolates from Australia identifies differences in the Pan-genomes between respiratory and cutaneous strains.BMC genomics · 2018Article
- The C-terminal coiled-coil domain of Corynebacterium diphtheriae DIP0733 is crucial for interaction with epithelial cells and pathogenicity in invertebrate animal model systems.BMC microbiology · 2018Article
- Genomic analyses reveal two distinct lineages ofNew microbes and new infections · 2018Article
- Adhesion properties of toxigenic corynebacteria.AIMS microbiology · 2018Review
- Article
- Adherence and invasive properties of Corynebacterium diphtheriae strains correlates with the predicted membrane-associated and secreted proteome.BMC genomics · 2015Article
- Corynebacterium diphtheriae putative tellurite-resistance protein (CDCE8392_0813) contributes to the intracellular survival in human epithelial cells and lethality of Caenorhabditis elegans.Memorias do Instituto Oswaldo Cruz · 2015Article
- Cell envelope of corynebacteria: structure and influence on pathogenicity.ISRN microbiology · 2013Article
- Contour and persistence length of Corynebacterium diphtheriae pili by atomic force microscopy.European biophysics journal : EBJ · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCorynebacterium diphtheriae, the causative agent of diphtheria, is well-investigated in respect to toxin production, while little is known about C. diphtheriae factors crucial for colonization of the host. In this study, we investigated strain-specific differences in adhesion, invasion and intracellular survival and analyzed formation of pili in different isolates.
resultsAdhesion of different C. diphtheriae strains to epithelial cells and invasion of these cells are not strictly coupled processes. Using ultrastructure analyses by atomic force microscopy, significant differences in macromolecular surface structures were found between the investigated C. diphtheriae strains in respect to number and length of pili. Interestingly, adhesion and pili formation are not coupled processes and also no correlation between invasion and pili formation was found. Using RNA hybridization and Western blotting experiments, strain-specific pili expression patterns were observed. None of the studied C. diphtheriae strains had a dramatic detrimental effect on host cell viability as indicated by measurements of transepithelial resistance of Detroit 562 cell monolayers and fluorescence microscopy, leading to the assumption that C. diphtheriae strains might use epithelial cells as an environmental niche supplying protection against antibodies and macrophages.
conclusionsThe results obtained suggest that it is necessary to investigate various isolates on a molecular level to understand and to predict the colonization process of different C. diphtheriae strains.
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