ArticleClinical and experimental immunology2010
Maternal country of origin, breast milk characteristics and potential influences on immunity in offspring.
Article in Clinical and experimental immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
- Presepsin in Human Milk Is Delivery Mode and Gender Dependent.Nutrients · 2024Article
- Human milk immune factors, maternal nutritional status, and infant sex: The INSPIRE study.American journal of human biology : the official journal of the Human Biology Council · 2023Article
- Exploring dynamic change and influencing factors of TGF-β1 and MUC1 in human breast milk, and their association with infantile diseases.Translational pediatrics · 2023Article
- Human Breast Milk: From Food to Active Immune Response With Disease Protection in Infants and Mothers.Frontiers in immunology · 2022Review
- Impact of Type of Parturition on Colostrum Microbiota Composition and Puppy Survival.Animals : an open access journal from MDPI · 2021Article
- Microbiota Composition of Breast Milk from Women of Different Ethnicity from the Manawatu-Wanganui Region of New Zealand.Nutrients · 2020Article
- Protective Effect of Breastfeeding on the Adverse Health Effects Induced by Air Pollution: Current Evidence and Possible Mechanisms.International journal of environmental research and public health · 2019Review
- Statistical Approaches in the Studies Assessing Associations between Human Milk Immune Composition and Allergic Diseases: A Scoping Review.Nutrients · 2019Article
- Article
- Variation among populations in the immune protein composition of mother's milk reflects subsistence pattern.Evolution, medicine, and public health · 2018Article
- Pasteurization Preserves IL-8 in Human Milk.Frontiers in pediatrics · 2018Article
- Impact of delivery mode on the colostrum microbiota composition.BMC microbiology · 2017Article
- Human Milk and Allergic Diseases: An Unsolved Puzzle.Nutrients · 2017Review
- What's Normal? Immune Profiling of Human Milk from Healthy Women Living in Different Geographical and Socioeconomic Settings.Frontiers in immunology · 2017Article
- Colostrum and Mature Human Milk of Women from London, Moscow, and Verona: Determinants of Immune Composition.Nutrients · 2016Article
- Nanoparticles of barium induce apoptosis in human phagocytes.International journal of nanomedicine · 2015Article
- Lactobacilli regulate Staphylococcus aureus 161:2-induced pro-inflammatory T-cell responses in vitro.PloS one · 2013Article
- Nutritionally mediated programming of the developing immune system.Advances in nutrition (Bethesda, Md.) · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast milk contains pro- and anti-inflammatory cytokines and chemokines with potential to influence immunological maturation in the child. We have shown previously that country of birth is associated with the cytokine/chemokine profile of breast milk. In this study we have investigated how these differences in breast milk affect the cellular response of cord blood mononuclear cells (CBMCs) and intestinal epithelial cells (IECs, cell line HT-29) to microbial challenge. Ninety-five women were included: 30 from Mali in West Africa, 32 Swedish immigrants and 33 native Swedish women. CBMCs or IECs were stimulated in vitro with breast milk, alone or in combination with lipopolysaccharide (LPS) or peptidoglycan (PGN). Breast milk in general abrogated the LPS-induced down-regulation of surface CD14 and Toll-like receptor (TLR)-4 expression on CB monocytes, while inhibiting the PGN-induced TLR-2 up-regulation. However, breast milk from immigrant women together with LPS induced a lower CBMC release of interleukin (IL)-6 (P = 0·034) and CXCL-8/IL-8 (P = 0·037) compared with breast milk from Swedish women, while breast milk from Swedish women and Mali women tended to increase the response. The same pattern of CXCL-8/IL-8 release could be seen after stimulation of IECs (HT-29). The lower CBMC and IEC (HT-29) responses to microbial compounds by breast milk from immigrant women could be explained by the fact that breast milk from the immigrant group showed a divergent pro- and anti-inflammatory content for CXCL-8/IL-8, transforming growth factor-β1 and soluble CD14, compared to the other two groups of women. This may have implications for maturation of their children's immune responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.