ArticleLangmuir : the ACS journal of surfaces and colloids2010
Cholesterol slows down the lateral mobility of an oxidized phospholipid in a supported lipid bilayer.
Article in Langmuir : the ACS journal of surfaces and colloids, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Oxidized Phosphatidylcholines Regulate Secretory Phospholipase AMolecules (Basel, Switzerland) · 2026Article
- Atherosclerotic Oxidized Lipids Affect Formation and Biophysical Properties of Supported Lipid Bilayers and Simulated Membranes.The journal of physical chemistry. B · 2024Article
- Effects of Nitro-Oxidative Stress on Biomolecules: Part 1-Non-Reactive Molecular Dynamics Simulations.Biomolecules · 2023Review
- Effect of magnesium sulfate in oxidized lipid bilayers properties by using molecular dynamics.Biochemistry and biophysics reports · 2021Article
- Article
- Peridinin Is an Exceptionally Potent and Membrane-Embedded Inhibitor of Bilayer Lipid Peroxidation.Journal of the American Chemical Society · 2018Article
- Proteins on Supported Lipid Bilayers Diffusing around Proteins Fixed on Acrylate Anchors.Analytical chemistry · 2018Article
- Cholesterol Protects the Oxidized Lipid Bilayer from Water Injury: An All-Atom Molecular Dynamics Study.The Journal of membrane biology · 2018Article
- Molecular-Scale Biophysical Modulation of an Endothelial Membrane by Oxidized Phospholipids.Biophysical journal · 2017Article
- Oxidized Phospholipids Inhibit the Formation of Cholesterol-Dependent Plasma Membrane Nanoplatforms.Biophysical journal · 2016Article
- Preparation of mica supported lipid bilayers for high resolution optical microscopy imaging.Journal of visualized experiments : JoVE · 2014Article
- Article
- Understanding the initiation of B cell signaling through live cell imaging.Methods in enzymology · 2012Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
We investigated the mobility and phase-partitioning of the fluorescent oxidized phospholipid analogue 1-palmitoyl-2-glutaroyl-sn-glycero-3-phospho-N-Alexa647-ethanolamine (PGPE-Alexa647) in supported lipid bilayers. Compared to the conventional phospholipid dihexadecanoylphosphoethanolamine (DHPE)-Bodipy we found consistently higher diffusion constants. The effect became dramatic when immobile obstacles were inserted into the bilayer, which essentially blocked the diffusion of DHPE-Bodipy but hardly influenced the movements of PGPE-Alexa647. In a supported lipid bilayer made of 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), the differences in probe mobility leveled off with increasing cholesterol content. Using coarse-grained molecular dynamics simulations, we could ascribe this effect to increased interactions between the oxidized phospholipid and the membrane matrix, concomitant with a translation in the headgroup position of the oxidized phospholipid: at zero cholesterol content, its headgroup is shifted to the outside of the DOPC headgroup region, whereas increasing cholesterol concentrations pulls the headgroup into the bilayer plane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.