ArticleFamilial cancer2011
Genetic epidemiological analysis reveals a multi-gene additive model for gastric cancer.
Article in Familial cancer, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Which Individuals with Positive Family History of Gastric Cancer Urgently Need Intensive Screening and Eradication of Helicobacter Pylori? A Systematic Review and Meta-Analysis.Iranian journal of public health · 2021Review
- Association between Genetic Polymorphisms in Superoxide Dismutase Gene Family and Risk of Gastric Cancer.Pathology oncology research : POR · 2020Article
- Non-random distribution of gastric cancer susceptible loci on human chromosomes.EXCLI journal · 2018Article
- Bayesian logistic regression in detection of gene-steroid interaction for cancer at PDLIM5 locus.Journal of genetics · 2016Article
- Susceptibility to gastric cancer and polymorphisms of insertion/deletion at the intron 3 of the XRCC4 and VNTR at the promoter region of the XRCC5.Pathology oncology research : POR · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A genetic epidemiologic analysis of gastric cancer in the Chinese Han population was conducted for 64 pedigrees (902 individuals) with gastric cancer and controls obtained from the population after a census was carried out in August 2007. The heritability of gastric cancer was performed using the Falconer method and the complex segregation analysis was performed using the Statistical Analysis for Genetic Epidemiology (S.A.G.E.) SEGREG program. The heritability of gastric cancer in first- and second-degree relatives was 54.75% (95% CI, 48.01-61.49%) and 44.97% (95% CI, 33.12-56.82%), respectively. The estimated segregation ratio of gastric cancer was 0.039 (95% CI, 0.017-0.061). The complex segregation analysis showed that the Mendelian inheritance of additive model provided the best fit to the data (AIC = 170.58, P > 0.05). Therefore, polygenetic or multi-factorial additive inheritance is involved in the genetic predisposition for the development of gastric cancer.
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