ArticlePLoS genetics2010
The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 167 citations in OpenAlex.
- Article
- Adaptations in electron transport chain complexes of clinical Rhodococcus equi revealed through comparative genomics.World journal of microbiology & biotechnology · 2026Article
- Antimicrobial Resistance inAntibiotics (Basel, Switzerland) · 2026Review
- Rhodopyran, a carboxylated hexahydrocyclopenta[Beilstein journal of organic chemistry · 2026Article
- Community Dynamics Drive Calcium Carbonate Production in an Enriched Consortium of Soil Microbes.Microbial ecology · 2025Article
- Reassessment of extracellular and intracellular activity of macrolides, rifampicin, and doxycycline againstMicrobiology spectrum · 2025Article
- Article
- Leveraging the subgenus category to address monophyletic genus over-splitting: illustration with recently proposedInternational journal of systematic and evolutionary microbiology · 2025Article
- Article
- Phenotypical and molecular characterization of Rhodococcus equi isolated from foals in the Agreste region of Pernambuco - Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Adaptive responses of Rhodococcus aetherivorans L13 to oligotrophy: genome and transcriptomic analysis.Current genetics · 2025Article
- Article
- LysR-Type Transcriptional Regulator VirR Responds to Temperature and pH and Directly Activates the Transcription ofInternational journal of microbiology · 2025Article
- Fruit residues as substrates for single-cell oil production by Rhodococcus species: physiology and genomics of carbohydrate catabolism.World journal of microbiology & biotechnology · 2024Article
- Article
- Identification of vaccine candidates againstHeliyon · 2023Article
- Genome analysis for the identification of genes involved in phenanthrene biodegradation pathway inFrontiers in bioengineering and biotechnology · 2023Article
- Adhesion of Rhodococcus bacteria to solid hydrocarbons and enhanced biodegradation of these compounds.Scientific reports · 2022Article
- Diversification of plasmids in a genus of pathogenic and nitrogen-fixing bacteria.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.Journal of clinical microbiology · 2021Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 11 institutions in 4 countries.
Funding
Abstract
We report the genome of the facultative intracellular parasite Rhodococcus equi, the only animal pathogen within the biotechnologically important actinobacterial genus Rhodococcus. The 5.0-Mb R. equi 103S genome is significantly smaller than those of environmental rhodococci. This is due to genome expansion in nonpathogenic species, via a linear gain of paralogous genes and an accelerated genetic flux, rather than reductive evolution in R. equi. The 103S genome lacks the extensive catabolic and secondary metabolic complement of environmental rhodococci, and it displays unique adaptations for host colonization and competition in the short-chain fatty acid-rich intestine and manure of herbivores--two main R. equi reservoirs. Except for a few horizontally acquired (HGT) pathogenicity loci, including a cytoadhesive pilus determinant (rpl) and the virulence plasmid vap pathogenicity island (PAI) required for intramacrophage survival, most of the potential virulence-associated genes identified in R. equi are conserved in environmental rhodococci or have homologs in nonpathogenic Actinobacteria. This suggests a mechanism of virulence evolution based on the cooption of existing core actinobacterial traits, triggered by key host niche-adaptive HGT events. We tested this hypothesis by investigating R. equi virulence plasmid-chromosome crosstalk, by global transcription profiling and expression network analysis. Two chromosomal genes conserved in environmental rhodococci, encoding putative chorismate mutase and anthranilate synthase enzymes involved in aromatic amino acid biosynthesis, were strongly coregulated with vap PAI virulence genes and required for optimal proliferation in macrophages. The regulatory integration of chromosomal metabolic genes under the control of the HGT-acquired plasmid PAI is thus an important element in the cooptive virulence of R. equi.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.