Evidence map›Paper›PMID 20940731›Full record

ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2011

Altered expression and function of ryanodine receptors and FKBP12.6 after subarachnoid hemorrhage: more than meets the eye.

William F Jackson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

William F JacksonDepartment of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA. jacks783@msu.edu
Michigan State University · US

Funding

Microcirculation in Aging Skeletal MuscleR01HL086483 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI SEGAL, STEVEN S · 2007 to 2012
$2.4M
SYNERGISM BETWEEN MODULATORS OF CEREBROVASCULAR TONEF32HL008648 · NHLBI · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI MURPHY, MICHAEL E · 1992 to 1994
–
NHLBI NIH HHS HL 086483ANHLBI NIH HHS R01 HL086483
6 · The paper itself

Abstract

Subarachnoid hemorrhage decreases the expression of ryanodine receptors and increases the expression of the immunophilin, FK506-binding protein (FKBP)12.6 in cerebrovascular smooth muscle cells, reducing the occurrence of Ca(2+) sparks, limiting negative feedback regulation of cerebrovascular tone and promoting vasospasm. However, given the large number of binding partners with which FKBP12.6 and related proteins interact, it appears likely that the altered expression of this immunophilin will have a broader impact on cerebrovascular smooth muscle function. In addition, the mechanisms responsible for the measured changes in expression of ryanodine receptors and FKBP12.6 yet remain unknown. These topics should prove to be fertile ground for future studies.

Indexed as

AnimalsCalcium SignalingCerebrovascular CirculationGene ExpressionMuscle, Smooth, VascularRabbitsRyanodine Receptor Calcium Release ChannelSubarachnoid HemorrhageTacrolimus Binding ProteinsRyanodine Receptor Calcium Release Channeltacrolimus binding protein 1BTacrolimus Binding Proteins

Identifiers

PMID20940731
PMCPMC3049468
OpenAlexW2076337209

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.